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Itk IL2 inducible T cell kinase [ Mus musculus (house mouse) ]

Gene ID: 16428, updated on 21-Apr-2024

Summary

Official Symbol
Itkprovided by MGI
Official Full Name
IL2 inducible T cell kinaseprovided by MGI
Primary source
MGI:MGI:96621
See related
Ensembl:ENSMUSG00000020395 AllianceGenome:MGI:96621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emt; Tsk; Tcsk
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; activation of phospholipase C activity; and gamma-delta T cell activation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 35.8), spleen adult (RPKM 4.7) and 1 other tissue See more
Orthologs
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Genomic context

Location:
11 B1.1; 11 27.75 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46215975..46280342, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46325148..46389515, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene fibronectin type III domain containing 9 Neighboring gene high mobility group box 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46124833-46125038 Neighboring gene STARR-positive B cell enhancer ABC_E8394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46140340-46140549 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46157730-46157921 Neighboring gene predicted gene 12167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46202936-46203219 Neighboring gene STARR-positive B cell enhancer ABC_E3943 Neighboring gene STARR-seq mESC enhancer starr_29325 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46234578-46234761 Neighboring gene golgi associated RAB2 interactor 3 Neighboring gene STARR-seq mESC enhancer starr_29326 Neighboring gene STARR-positive B cell enhancer ABC_E1415 Neighboring gene mediator complex subunit 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in NK T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within NK T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gamma-delta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within interleukin-4 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
tyrosine-protein kinase ITK/TSK
Names
T-cell-specific kinase
interleukin-2-inducible T cell kinase
kinase TLK
NP_001268894.1
NP_001268895.1
NP_001268896.1
NP_001268897.1
NP_034713.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281965.1NP_001268894.1  tyrosine-protein kinase ITK/TSK isoform 1

    See identical proteins and their annotated locations for NP_001268894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK153613, AL662806, BB843988, BY589043, D14042
    Consensus CDS
    CCDS70169.1
    UniProtKB/Swiss-Prot
    Q03526
    UniProtKB/TrEMBL
    Q3U5G1
    Related
    ENSMUSP00000104860.3, ENSMUST00000109237.9
    Conserved Domains (4) summary
    cd05112
    Location:363618
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:238345
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:180235
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7154
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
  2. NM_001281966.1NP_001268895.1  tyrosine-protein kinase ITK/TSK isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK153613, BB843988, BY589043, D14042
    UniProtKB/TrEMBL
    Q3U5G1
    Conserved Domains (4) summary
    cd05112
    Location:360615
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:235342
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:177232
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
  3. NM_001281967.1NP_001268896.1  tyrosine-protein kinase ITK/TSK isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BB843988, BC028478
    Consensus CDS
    CCDS70168.1
    UniProtKB/TrEMBL
    Q5STT7
    Related
    ENSMUSP00000098864.4, ENSMUST00000101306.4
    Conserved Domains (4) summary
    cd11908
    Location:174229
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:5111
    PH; PH domain
    cl15255
    Location:232259
    SH2; Src homology 2 (SH2) domain
  4. NM_001281968.1NP_001268897.1  tyrosine-protein kinase ITK/TSK isoform 5

    See identical proteins and their annotated locations for NP_001268897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.
    Source sequence(s)
    AK153613, BB843988, BY589043, D14042
    UniProtKB/TrEMBL
    A1A560, Q3U5G1
    Conserved Domains (4) summary
    cd05112
    Location:356611
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:231338
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:173228
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7147
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
  5. NM_010583.3NP_034713.2  tyrosine-protein kinase ITK/TSK isoform 2

    See identical proteins and their annotated locations for NP_034713.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK153613, BB843988, BY589043, D14042
    Consensus CDS
    CCDS24575.2
    UniProtKB/TrEMBL
    Q3U5G1, Q5STT8
    Related
    ENSMUSP00000020664.7, ENSMUST00000020664.13
    Conserved Domains (4) summary
    cd05112
    Location:357612
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:232339
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:174229
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    46215975..46280342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)