MACROD1 mono-ADP ribosylhydrolase 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: MACROD1provided by VGNC
Official Full Name: mono-ADP ribosylhydrolase 1provided by VGNC
Primary source: VGNC:VGNC:98096
See related: Ensembl:ENSSSCG00000013043
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in longissimus dorsi muscle (RPKM 242.5), psoas major muscle (RPKM 184.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (7939125..8087656)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (7054730..7204542)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_17465-17466:1022854475:1 (e-PCR)
- UniSTS:268307

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ADP-ribosylglutamate hydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptidyl-glutamate ADP-deribosylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in purine nucleoside metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ADP-ribose glycohydrolase MACROD1

Names: MACRO domain containing 1

NP_001191699.1

EC 3.1.1.106

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204770.1 → NP_001191699.1 ADP-ribose glycohydrolase MACROD1

See identical proteins and their annotated locations for NP_001191699.1

Status: PROVISIONAL

Source sequence(s)

HQ645868

UniProtKB/TrEMBL

A0A4X1VCP7, A0A8D0VMJ0, E7EBY5

Related

ENSSSCP00000013870.3, ENSSSCT00000014256.5

Conserved Domains (2) summary

COG2110
Location:152 → 314

YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]

cd02908
Location:153 → 319

Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...