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BRAF B-Raf proto-oncogene, serine/threonine kinase [ Sus scrofa (pig) ]

Gene ID: 100514612, updated on 17-Aug-2024

Summary

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Official Symbol
BRAFprovided by VGNC
Official Full Name
B-Raf proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:85866
See related
Ensembl:ENSSSCG00000016494
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in kidney (RPKM 3.3), lung (RPKM 3.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
24
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 18 NC_010460.4 (8957963..9132558)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 18 NC_010460.3 (9522257..9636501)

Chromosome 18 - NC_010460.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene cyclin-I pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene aarF domain containing kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase B-raf
Names
v-raf murine sarcoma viral oncogene homolog B
v-raf murine sarcoma viral oncogene homolog B1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010460.4 Reference Sscrofa11.1 Primary Assembly

    Range
    8957963..9132558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021078584.1 → XP_020934243.1  serine/threonine-protein kinase B-raf isoform X2

    UniProtKB/TrEMBL
    A0A481A5U7
    Related
    ENSSSCP00000031829.1, ENSSSCT00000055445.2
    Conserved Domains (3) summary
    cd01816
    Location:153 → 224
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:460 → 712
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:232 → 277
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_021078585.1 → XP_020934244.1  serine/threonine-protein kinase B-raf isoform X3

    UniProtKB/TrEMBL
    A0A481A5U7
    Conserved Domains (3) summary
    cd01816
    Location:153 → 224
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:460 → 712
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:232 → 277
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_021078587.1 → XP_020934246.1  serine/threonine-protein kinase B-raf isoform X5

    UniProtKB/TrEMBL
    A0A4X1V2V1, F1SRQ1
    Related
    ENSSSCP00000017476.4, ENSSSCT00000017958.5
    Conserved Domains (3) summary
    cd01816
    Location:153 → 224
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:432 → 684
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:232 → 277
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_021078586.1 → XP_020934245.1  serine/threonine-protein kinase B-raf isoform X4

    UniProtKB/TrEMBL
    A0A481A5U7
    Conserved Domains (3) summary
    cd01816
    Location:153 → 224
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:472 → 718
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:232 → 277
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  5. XM_021078583.1 → XP_020934242.1  serine/threonine-protein kinase B-raf isoform X1

    UniProtKB/TrEMBL
    A0A481A5U7
    Conserved Domains (3) summary
    cd01816
    Location:153 → 224
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:472 → 724
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:232 → 277
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  6. XM_021078588.1 → XP_020934247.1  serine/threonine-protein kinase B-raf isoform X6

    UniProtKB/TrEMBL
    A0A286ZJW4, A0A4X1V741
    Conserved Domains (3) summary
    cd01816
    Location:104 → 175
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:423 → 675
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:183 → 228
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  7. XM_005654267.3 → XP_005654324.1  serine/threonine-protein kinase B-raf isoform X6

    UniProtKB/TrEMBL
    A0A286ZJW4, A0A4X1V741
    Conserved Domains (3) summary
    cd01816
    Location:104 → 175
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:423 → 675
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:183 → 228
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. XR_002340233.1 RNA Sequence

    Related
    ENSSSCT00000040418.3

  2. XR_002340234.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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