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Braf Braf transforming gene [ Mus musculus (house mouse) ]

Gene ID: 109880, updated on 8-Feb-2024

Summary

Official Symbol
Brafprovided by MGI
Official Full Name
Braf transforming geneprovided by MGI
Primary source
MGI:MGI:88190
See related
Ensembl:ENSMUSG00000002413 AllianceGenome:MGI:88190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B-raf; Braf2; Braf-2; C230098H17; D6Ertd631e; 9930012E13Rik
Summary
Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 6.7), bladder adult (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

See Braf in Genome Data Viewer
Location:
6 B1; 6 18.43 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39580171..39702592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39603231..39725658, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene predicted gene, 34389 Neighboring gene ferritin heavy chain, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_15669 Neighboring gene STARR-seq mESC enhancer starr_15670 Neighboring gene STARR-seq mESC enhancer starr_15671 Neighboring gene STARR-positive B cell enhancer ABC_E6425 Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene predicted gene 7554

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (24)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within face development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within head morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of axon regeneration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in trehalose metabolism in response to stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase B-raf
Names
B-Raf proto-oncogene serine/threonine-protein kinase (p94)
proto-oncogene B-Raf
NP_647455.3
XP_006505416.1
XP_006505418.1
XP_006505421.1
XP_011239436.1
XP_011239437.1
XP_011239438.2
XP_011239439.2
XP_011239440.1
XP_011239441.1
XP_030110954.1
XP_030110955.1
XP_036021639.1
XP_036021640.1
XP_036021641.1
XP_036021642.1
XP_036021643.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139294.5NP_647455.3  serine/threonine-protein kinase B-raf

    See identical proteins and their annotated locations for NP_647455.3

    Status: VALIDATED

    Source sequence(s)
    AC122345, AC163109, AK140431, BF466677, CK393545
    Consensus CDS
    CCDS39463.1
    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Related
    ENSMUSP00000002487.9, ENSMUST00000002487.15
    Conserved Domains (4) summary
    cd01816
    Location:140211
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:500752
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00069
    Location:495750
    Pkinase; Protein kinase domain
    pfam00130
    Location:219264
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39580171..39702592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165750.1XP_036021643.1  serine/threonine-protein kinase B-raf isoform X16

    Conserved Domains (3) summary
    cd14062
    Location:558804
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248326
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:324383
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
  2. XM_006505358.5XP_006505421.1  serine/threonine-protein kinase B-raf isoform X13

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Related
    ENSMUSP00000099036.4, ENSMUST00000101497.4
    Conserved Domains (3) summary
    cd14062
    Location:558810
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248326
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:329374
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  3. XM_006505355.5XP_006505418.1  serine/threonine-protein kinase B-raf isoform X5

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:598850
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248326
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:329374
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  4. XM_036165747.1XP_036021640.1  serine/threonine-protein kinase B-raf isoform X10

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:570822
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248326
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:324383
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
  5. XM_006505353.5XP_006505416.1  serine/threonine-protein kinase B-raf isoform X3

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:610862
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248326
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:329374
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  6. XM_011241139.4XP_011239441.1  serine/threonine-protein kinase B-raf isoform X12

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:561813
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248329
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:332377
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  7. XM_011241135.4XP_011239437.1  serine/threonine-protein kinase B-raf isoform X4

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:601853
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248329
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:332377
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  8. XM_011241138.4XP_011239440.1  serine/threonine-protein kinase B-raf isoform X8

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:573825
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248329
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:332377
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  9. XM_011241134.4XP_011239436.1  serine/threonine-protein kinase B-raf isoform X1

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:613865
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248329
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:332377
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  10. XM_036165746.1XP_036021639.1  serine/threonine-protein kinase B-raf isoform X2

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:613865
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:248329
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:327386
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
  11. XM_011241137.3XP_011239439.2  serine/threonine-protein kinase B-raf isoform X7

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:574826
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:209290
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:293338
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  12. XM_011241136.4XP_011239438.2  serine/threonine-protein kinase B-raf isoform X6

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:580832
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:215296
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:299344
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  13. XM_030255094.2XP_030110954.1  serine/threonine-protein kinase B-raf isoform X9

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:571823
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:209287
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:290335
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  14. XM_036165748.1XP_036021641.1  serine/threonine-protein kinase B-raf isoform X14

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:463715
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:138219
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:217276
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
  15. XM_030255095.2XP_030110955.1  serine/threonine-protein kinase B-raf isoform X11

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:488740
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:138216
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    pfam00130
    Location:219264
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  16. XM_036165749.1XP_036021642.1  serine/threonine-protein kinase B-raf isoform X15

    UniProtKB/Swiss-Prot
    E9QNG9, F6SZ47, P28028, Q3USE9
    Conserved Domains (3) summary
    cd14062
    Location:448700
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:138216
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:214273
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

RNA

  1. XR_004942909.1 RNA Sequence

  2. XR_004942908.1 RNA Sequence

  3. XR_001785085.2 RNA Sequence

  4. XR_001785086.3 RNA Sequence

  5. XR_001785087.2 RNA Sequence