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SQSTM1 sequestosome 1 [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100172461, updated on 6-Jun-2024

Summary

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Gene symbol
SQSTM1
Gene description
sequestosome 1
Locus tag
CR201_G0044167
See related
Ensembl:ENSPPYG00000016130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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See SQSTM1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 4 NC_071989.2 (188570977..188600448)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 5 NC_071990.1 (187652354..187667093)

Chromosome 4 - NC_071989.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100936663 Neighboring gene leukotriene C4 synthase Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene MRN complex interacting protein Neighboring gene uncharacterized LOC129059726 Neighboring gene TBC1 domain family member 9B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • DKFZp468L2213

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aggrephagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in aggresome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in amphisome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sequestosome-1
Names
ubiquitin-binding protein p62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001132076.2 → NP_001125548.2  sequestosome-1

    Status: VALIDATED

    Source sequence(s)
    JAQQLQ020000004
    UniProtKB/TrEMBL
    A0A2J8SCU6, A0A2J8SCX3, A0A8I5TCG9

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071989.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    188570977..188600448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063724566.1 → XP_063580636.1  sequestosome-1 isoform X3

    UniProtKB/TrEMBL
    A0A2J8SCX2, A0A2J8SCX3, A0A8I5UCQ3

  2. XM_063724567.1 → XP_063580637.1  sequestosome-1 isoform X4

    UniProtKB/TrEMBL
    A0A2J8SCX3

  3. XM_063724565.1 → XP_063580635.1  sequestosome-1 isoform X4

    UniProtKB/TrEMBL
    A0A2J8SCX3

  4. XM_063724561.1 → XP_063580631.1  sequestosome-1 isoform X3

    UniProtKB/TrEMBL
    A0A2J8SCX2, A0A2J8SCX3, A0A8I5UCQ3

  5. XM_063724563.1 → XP_063580633.1  sequestosome-1 isoform X4

    UniProtKB/TrEMBL
    A0A2J8SCX3

  6. XM_063724562.1 → XP_063580632.1  sequestosome-1 isoform X4

    UniProtKB/TrEMBL
    A0A2J8SCX3

  7. XM_009241370.4 → XP_009239645.2  sequestosome-1 isoform X1

    Related
    ENSPPYP00000034065.1
    Conserved Domains (3) summary
    cd06402
    Location:4 → 102
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:126 → 168
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    pfam16577
    Location:379 → 440
    UBA_5; UBA domain

  8. XM_063724560.1 → XP_063580630.1  sequestosome-1 isoform X2

    UniProtKB/Swiss-Prot
    Q5RBA5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RBA5.1 GenPept UniProtKB/Swiss-Prot:Q5RBA5

Gene LinkOut

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