PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: PRKAA2
Gene description: protein kinase AMP-activated catalytic subunit alpha 2
Locus tag: CR201_G0021112
See related: Ensembl:ENSPPYG00000001303
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	1	NC_071985.2 (176439053..176505870, complement)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	1	NC_071985.1 (176450699..176512780, complement)

Chromosome 1 - NC_071985.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1S2690 (e-PCR), detects polymorphism
- UniSTS:14341

PRKAA2 (e-PCR)
- UniSTS:479768

D1S2084 (e-PCR)
- UniSTS:49232

GDB:573976 (e-PCR)
- UniSTS:157783

SHGC-35382 (e-PCR)
- UniSTS:68708

PRKAA2_1075 (e-PCR)
- UniSTS:277615

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5'-AMP-activated protein kinase catalytic subunit alpha-2

Names: ACACA kinase; AMPK subunit alpha-2; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 2 catalytic subunit

NP_001125173.1

EC 2.7.11.1

EC 2.7.11.31

XP_063580386.1

EC 2.7.11.1

EC 2.7.11.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131701.2 → NP_001125173.1 5'-AMP-activated protein kinase catalytic subunit alpha-2

See identical proteins and their annotated locations for NP_001125173.1

Status: PROVISIONAL

Source sequence(s)

CR858118

UniProtKB/Swiss-Prot

Q5RD00

UniProtKB/TrEMBL

A0A2J8V963

Related

ENSPPYP00000001519.2, ENSPPYT00000001567.3

Conserved Domains (4) summary

cd12200
Location:395 → 550

AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha

smart00220
Location:16 → 268

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14404
Location:285 → 349

UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)

cd14079
Location:13 → 268

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_071985.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

176439053..176505870 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)