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Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 108079, updated on 27-Nov-2024

Summary

Official Symbol
Prkaa2provided by MGI
Official Full Name
protein kinase, AMP-activated, alpha 2 catalytic subunitprovided by MGI
Primary source
MGI:MGI:1336173
See related
Ensembl:ENSMUSG00000028518 AllianceGenome:MGI:1336173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A830082D05; AMPKalpha2; 2310008I11Rik
Summary
Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 10.8), kidney adult (RPKM 9.5) and 18 other tissues See more
Orthologs
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Genomic context

See Prkaa2 in Genome Data Viewer
Location:
4 C6; 4 49.05 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (104886846..104967095, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (105029649..105109898, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene FYN binding protein 2 Neighboring gene predicted gene 12721 Neighboring gene predicted gene, 52670 Neighboring gene VISTA enhancer mm1176 Neighboring gene predicted gene, 36893 Neighboring gene predicted gene, 29838

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables AMP-activated protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables AMP-activated protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables AMP-activated protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to prostaglandin E stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid droplet disassembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect lipid droplet disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peptidyl-lysine acetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to lipid droplet ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of stress granule assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to caffeine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to muscle activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-2
Names
ACACA kinase
AMPK subunit alpha-2
HMGCR kinase
acetyl-CoA carboxylase kinase
hydroxymethylglutaryl-CoA reductase kinase
NP_001343497.1
NP_835279.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356568.1NP_001343497.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK009231, AK020297, AK044030, AL627307, AL929466, CJ283122, CK618328, CX563939
    Conserved Domains (3) summary
    cd14404
    Location:195259
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cl17070
    Location:305460
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains
    cl21453
    Location:1178
    PKc_like; Protein Kinases, catalytic domain
  2. NM_178143.2NP_835279.2  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1

    See identical proteins and their annotated locations for NP_835279.2

    Status: VALIDATED

    Source sequence(s)
    AL627307, AL929466, BC138565
    Consensus CDS
    CCDS18416.1
    UniProtKB/Swiss-Prot
    B1ASQ8, Q3UYM4, Q8BRK8
    Related
    ENSMUSP00000030243.8, ENSMUST00000030243.8
    Conserved Domains (3) summary
    cd14404
    Location:285349
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cd14079
    Location:13268
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
    cl17070
    Location:395550
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    104886846..104967095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)