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POR cytochrome p450 oxidoreductase [ Sus scrofa (pig) ]

Gene ID: 100170114, updated on 17-Aug-2024

Summary

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Official Symbol
PORprovided by VGNC
Official Full Name
cytochrome p450 oxidoreductaseprovided by VGNC
Primary source
VGNC:VGNC:109477
See related
Ensembl:ENSSSCG00000038320
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in liver (RPKM 59.2), subcutaneous adipose (RPKM 38.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (10212734..10272184, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003538795.2 (28999..55077)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase 2 Neighboring gene serine/threonine/tyrosine interacting like 1 Neighboring gene transmembrane protein 120A Neighboring gene uncharacterized LOC110259894 Neighboring gene rhomboid domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Complete amino acid sequence of NADPH-cytochrome P-450 reductase from porcine hepatic microsomes. Haniu M, et al. Biochemistry, 1986 Dec 2. PMID 3099837
  2. Complete structure of the hydrophilic domain in the porcine NADPH-cytochrome P-450 reductase. Vogel F, et al. Biochem J, 1986 Jun 15. PMID 3098240, Free PMC Article
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables NADPH-hemoprotein reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NADPH--cytochrome P450 reductase
Names
CPR
NADPH-cytochrome P-450 oxidoreductase
P450 (cytochrome) oxidoreductase
P450R
NP_001123431.1
XP_020941211.1
XP_020941212.1
XP_020941213.1
XP_020941214.1
XP_020941215.1
XP_020941216.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129959.1 → NP_001123431.1  NADPH--cytochrome P450 reductase

    See identical proteins and their annotated locations for NP_001123431.1

    Status: PROVISIONAL

    Source sequence(s)
    L33893
    UniProtKB/TrEMBL
    A0A480ITB0, A0A8D1YYT2
    Related
    ENSSSCP00000058964.1, ENSSSCT00000060878.3
    Conserved Domains (3) summary
    cd06204
    Location:277 → 677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:52 → 677
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:82 → 219
    Flavodoxin_1; Flavodoxin

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    10212734..10272184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021085556.1 → XP_020941215.1  NADPH--cytochrome P450 reductase isoform X2

    UniProtKB/TrEMBL
    A0A480F3I9, A0A480ITB0, A0A4X1ULW5, A0A8D1YYT2
    Conserved Domains (2) summary
    cd06204
    Location:277 → 677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82 → 219
    Flavodoxin_1

  2. XM_021085553.1 → XP_020941212.1  NADPH--cytochrome P450 reductase isoform X2

    UniProtKB/TrEMBL
    A0A480F3I9, A0A480ITB0, A0A4X1ULW5, A0A8D1YYT2
    Related
    ENSSSCP00000047375.2, ENSSSCT00000062325.2
    Conserved Domains (2) summary
    cd06204
    Location:277 → 677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82 → 219
    Flavodoxin_1

  3. XM_021085554.1 → XP_020941213.1  NADPH--cytochrome P450 reductase isoform X2

    UniProtKB/TrEMBL
    A0A480F3I9, A0A480ITB0, A0A4X1ULW5, A0A8D1YYT2
    Conserved Domains (2) summary
    cd06204
    Location:277 → 677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82 → 219
    Flavodoxin_1

  4. XM_021085557.1 → XP_020941216.1  NADPH--cytochrome P450 reductase isoform X2

    UniProtKB/TrEMBL
    A0A480F3I9, A0A480ITB0, A0A4X1ULW5, A0A8D1YYT2
    Conserved Domains (2) summary
    cd06204
    Location:277 → 677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82 → 219
    Flavodoxin_1

  5. XM_021085552.1 → XP_020941211.1  NADPH--cytochrome P450 reductase isoform X1

    UniProtKB/TrEMBL
    A0A8D1EEW5
    Conserved Domains (2) summary
    cd06204
    Location:309 → 709
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:114 → 251
    Flavodoxin_1

  6. XM_021085555.1 → XP_020941214.1  NADPH--cytochrome P450 reductase isoform X2

    UniProtKB/TrEMBL
    A0A480F3I9, A0A480ITB0, A0A4X1ULW5, A0A8D1YYT2
    Related
    ENSSSCP00000036096.1, ENSSSCT00000053539.3
    Conserved Domains (2) summary
    cd06204
    Location:277 → 677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82 → 219
    Flavodoxin_1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04175.2 GenPept UniProtKB/Swiss-Prot:P04175

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