sphk2 sphingosine kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sphk2provided by ZNC
Official Full Name: sphingosine kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-100922-225
See related: Ensembl:ENSDARG00000069893 AllianceGenome:ZFIN:ZDB-GENE-100922-225
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-40m6.13
Summary: Predicted to enable D-erythro-sphingosine kinase activity and lipid kinase activity. Acts upstream of or within several processes, including animal organ development; cellular response to ceramide; and sphingolipid mediated signaling pathway. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including blastodisc; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Used to study non-alcoholic steatohepatitis. Orthologous to human SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (32131661..32146014)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (32177570..32191984)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish.
Title: 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-erythro-sphingosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration to the midline involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to ceramide	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphinganine-1-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sphingolipid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sphingosine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info