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MMP2 matrix metallopeptidase 2 [ Ornithorhynchus anatinus (platypus) ]

Gene ID: 100077120, updated on 30-Apr-2024

Summary

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Gene symbol
MMP2
Gene description
matrix metallopeptidase 2
See related
Ensembl:ENSOANG00000011098
Gene type
protein coding
RefSeq status
MODEL
Organism
Ornithorhynchus anatinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus
Also known as
MMP9
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
13
Annotation release Status Assembly Chr Location
105 current mOrnAna1.pri.v4 (GCF_004115215.2) 11 NC_041738.1 (4701893..4719231, complement)

Chromosome 11 - NC_041738.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 2 Neighboring gene small nucleolar RNA SNORA7 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain small subunit 2 Neighboring gene iroquois homeobox 6 Neighboring gene small nucleolar RNA SNORA7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_041738.1 Chromosome 11 Reference mOrnAna1.pri.v4 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
72 kDa type IV collagenase
Names
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
matrix metallopeptidase 9

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ornithorhynchus anatinus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrnAna1.pri.v4 Primary Assembly

Genomic

  1. NC_041738.1 Reference mOrnAna1.pri.v4 Primary Assembly

    Range
    4701893..4719231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007669433.3 → XP_007667623.1  72 kDa type IV collagenase

    UniProtKB/TrEMBL
    A0A6I8PQL3, F7FCH2
    Related
    ENSOANP00000017583.3
    Conserved Domains (5) summary
    smart00059
    Location:282 → 330
    FN2; Fibronectin type 2 domain
    cd00094
    Location:462 → 656
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:116 → 444
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:116 → 444
    Peptidase_M10; Matrixin
    pfam01471
    Location:68 → 95
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein
Heading Accession and Version

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