selenom selenoprotein M [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: selenomprovided by Xenbase
Official Full Name: selenoprotein Mprovided by Xenbase
Primary source: Xenbase:XB-GENE-5769563
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: selm; sepm
Summary: The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known, but it may have a role in maintaining redox homeostasis. It is localized in the perinuclear region, and is highly expressed in the brain in mammals. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (144036742..144043679, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (131607857..131614851, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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General protein information

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Preferred Names: selenoprotein M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171607.2 → NP_001165078.1 selenoprotein M precursor

Status: REVIEWED

Source sequence(s)

BC135126, DR861705, EL711654

UniProtKB/TrEMBL

A0A8J0QDF7

Conserved Domains (1) summary

pfam08806
Location:30 → 104

Sep15_SelM; Sep15/SelM redox domain