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Selenom selenoprotein M [ Mus musculus (house mouse) ]

Gene ID: 114679, updated on 25-Sep-2020

Summary

Official Symbol
Selenomprovided by MGI
Official Full Name
selenoprotein Mprovided by MGI
Primary source
MGI:MGI:2149786
See related
Ensembl:ENSMUSG00000075702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Se; Selm; Sepm; A230103K18; 1500040L08Rik
Summary
The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]
Expression
Broad expression in colon adult (RPKM 163.0), cerebellum adult (RPKM 154.9) and 22 other tissues See more
Orthologs

Genomic context

See Selenom in Genome Data Viewer
Location:
11; 11 A1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3464684..3467351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3514684..3517351)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (3414705..3417354)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene uncharacterized LOC118567888 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene phospholipase A2, group III Neighboring gene inositol polyphosphate 5-phosphatase J Neighboring gene smoothelin Neighboring gene predicted gene 11946 Neighboring gene predicted gene, 34488

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
corticosterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to selenium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053267.3NP_444497.1  selenoprotein M precursor

    See identical proteins and their annotated locations for NP_444497.1

    Status: REVIEWED

    Source sequence(s)
    AW049879, BB589016, BC147333
    Consensus CDS
    CCDS24365.1
    UniProtKB/Swiss-Prot
    Q8VHC3
    Related
    ENSMUSP00000092041.4, ENSMUST00000094469.4
    Conserved Domains (1) summary
    pfam08806
    Location:40114
    Sep15_SelM; Sep15/SelM redox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3464684..3467351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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