U.S. flag

An official website of the United States government


Send to:

Choose Destination

Selenom selenoprotein M [ Mus musculus (house mouse) ]

Gene ID: 114679, updated on 9-May-2024


Official Symbol
Selenomprovided by MGI
Official Full Name
selenoprotein Mprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000075702 AllianceGenome:MGI:2149786
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Selm; Sepm; A230103K18; 1500040L08Rik
The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]
Broad expression in colon adult (RPKM 163.0), cerebellum adult (RPKM 154.9) and 22 other tissues See more
Try the new Gene table
Try the new Transcript table

Genomic context

See Selenom in Genome Data Viewer
11 A1; 11 2.47 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3464684..3467351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3514684..3517351)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene predicted gene, 53661 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene phospholipase A2, group III Neighboring gene inositol polyphosphate 5-phosphatase J Neighboring gene smoothelin Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3435535-3435644 Neighboring gene STARR-positive B cell enhancer mm9_chr11:3439140-3439441 Neighboring gene predicted gene 11946 Neighboring gene STARR-seq mESC enhancer starr_28360 Neighboring gene predicted gene, 34488

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053267.3NP_444497.1  selenoprotein M precursor

    See identical proteins and their annotated locations for NP_444497.1

    Status: REVIEWED

    Source sequence(s)
    AW049879, BB589016, BC147333
    Consensus CDS
    B2RVS9, Q3V374, Q8CBT7, Q8VCJ0, Q8VHC3
    ENSMUSP00000092041.6, ENSMUST00000094469.6
    Conserved Domains (1) summary
    Sep15_SelM; Sep15/SelM redox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000077.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)