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SELENOM selenoprotein M [ Homo sapiens (human) ]

Gene ID: 140606, updated on 5-Jan-2022


Official Symbol
SELENOMprovided by HGNC
Official Full Name
selenoprotein Mprovided by HGNC
Primary source
See related
Ensembl:ENSG00000198832 MIM:610918
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]
Ubiquitous expression in prostate (RPKM 54.6), endometrium (RPKM 49.8) and 23 other tissues See more
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Genomic context

See SELENOM in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (31104777..31107568, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31500763..31503554, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 633, pseudogene Neighboring gene smoothelin Neighboring gene uncharacterized LOC105372995 Neighboring gene inositol polyphosphate-5-phosphatase J Neighboring gene ribosomal protein S15a pseudogene 37 Neighboring gene phospholipase A2 group III

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC40146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in adipose tissue development IEA
Inferred from Electronic Annotation
more info
involved_in corticosterone secretion IEA
Inferred from Electronic Annotation
more info
involved_in hormone metabolic process IEA
Inferred from Electronic Annotation
more info
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
involved_in response to selenium ion IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
selenoprotein M
selenoprotein SelM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080430.4NP_536355.1  selenoprotein M precursor

    See identical proteins and their annotated locations for NP_536355.1

    Status: REVIEWED

    Source sequence(s)
    BC068004, HY137180
    Consensus CDS
    ENSP00000383155.2, ENST00000400299.6
    Conserved Domains (1) summary
    Sep15_SelM; Sep15/SelM redox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    31104777..31107568 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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