Presenilin - Structure - NCBI

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Select item 1059911.

Molecular Structure Image for 4HYG

Structure of a presenilin family intramembrane aspartate protease in C222 space group[MEMBRANE PROTEIN]

Taxonomy:: Methanoculleus marisnigri JR1

Proteins:: 4
modified:: 2024-03-20

MMDB ID:: 105991
PDB ID:: 4HYG

View in iCn3D Similar Structures PubMed Proteins Conserved Domains

Select item 1059902.

Molecular Structure Image for 4HYD

Structure of a presenilin family intramembrane aspartate protease in C2221 space group[MEMBRANE PROTEIN]

Taxonomy:: Methanoculleus marisnigri JR1

Proteins:: 4
modified:: 2024-03-20

MMDB ID:: 105990
PDB ID:: 4HYD

View in iCn3D Similar Structures PubMed Proteins Conserved Domains

Select item 1059893.

Molecular Structure Image for 4HYC

Structure of a presenilin family intramembrane aspartate protease in P2 space group[MEMBRANE PROTEIN]

Taxonomy:: Methanoculleus marisnigri JR1

Proteins:: 4
modified:: 2024-03-20

MMDB ID:: 105989
PDB ID:: 4HYC

View in iCn3D Similar Structures PubMed Proteins Conserved Domains

Select item 1279614.

Molecular Structure Image for 4Y6K

Complex structure of presenilin homologue PSH bound to an inhibitor[MEMBRANE PROTEIN/INHIBITOR]

Taxonomy:: Methanoculleus marisnigri JR1

Proteins:: 4
modified:: 2023-11-11

MMDB ID:: 127961
PDB ID:: 4Y6K

View in iCn3D Similar Structures PubMed Proteins Conserved Domains PubChem Compound

Select item 2224985.

Molecular Structure Image for 7Y5Z

CryoEM structure of human PS2-containing gamma-secretase[MEMBRANE PROTEIN/HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 4
Chemicals:: 25
modified:: 2024-11-04

MMDB ID:: 222498
PDB ID:: 7Y5Z

View in iCn3D Similar Structures PubMed Proteins Conserved Domains PubChem Compound

Select item 2224976.

Molecular Structure Image for 7Y5X

CryoEM structure of PS2-containing gamma-secretase treated with MRK-560[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens

Proteins:: 4
Chemicals:: 26
modified:: 2024-11-04

MMDB ID:: 222497
PDB ID:: 7Y5X

View in iCn3D Similar Structures PubMed Proteins Conserved Domains PubChem Compound

Select item 2224967.

Molecular Structure Image for 7Y5T

CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560[MEMBRANE PROTEIN/HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 4
Chemicals:: 27
modified:: 2024-11-04

MMDB ID:: 222496
PDB ID:: 7Y5T

View in iCn3D Similar Structures PubMed Proteins Conserved Domains PubChem Compound

Select item 1459238.

Molecular Structure Image for 5FN5

Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble[HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 4
modified:: 2024-10-24

MMDB ID:: 145923
PDB ID:: 5FN5

View in iCn3D Similar Structures PubMed Proteins Conserved Domains

Select item 1459229.

Molecular Structure Image for 5FN4

Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble[HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 5
modified:: 2024-10-24

MMDB ID:: 145922
PDB ID:: 5FN4

View in iCn3D Similar Structures PubMed Proteins Conserved Domains

Select item 14592110.

Molecular Structure Image for 5FN2

Cryo-EM structure of gamma secretase in complex with a drug DAPT[HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 4
modified:: 2019-09-17

MMDB ID:: 145921
PDB ID:: 5FN2

View in iCn3D Similar Structures PubMed Proteins Conserved Domains

Select item 13493411.

Molecular Structure Image for 5FN3

Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble[HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 5
modified:: 2024-10-10

MMDB ID:: 134934
PDB ID:: 5FN3

View in iCn3D Similar Structures PubMed Proteins Conserved Domains

Select item 13151012.

Molecular Structure Image for 5A63

Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution[HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 4
Chemicals:: 22
modified:: 2019-09-17

MMDB ID:: 131510
PDB ID:: 5A63

View in iCn3D Similar Structures PubMed Proteins Conserved Domains PubChem Compound

Select item 24199513.

Molecular Structure Image for 8K8E

Human gamma-secretase in complex with a substrate mimetic[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens, synthetic construct

Proteins:: 5
Chemicals:: 15
modified:: 2024-03-05

MMDB ID:: 241995
PDB ID:: 8K8E

View in iCn3D Similar Structures PubMed Proteins PubChem Compound

Select item 17073114.

Molecular Structure Image for 6IYC

Recognition of the Amyloid Precursor Protein by Human gamma-secretase[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens

Proteins:: 5
Chemicals:: 26
modified:: 2019-11-08

MMDB ID:: 170731
PDB ID:: 6IYC

View in iCn3D Similar Structures PubMed Proteins Conserved Domains PubChem Compound

Select item 8163015.

Molecular Structure Image for 2KR6

Solution structure of presenilin-1 CTF subunit[HYDROLASE]

Taxonomy:: Homo sapiens

Proteins:: 1
modified:: 2024-05-08

MMDB ID:: 81630
PDB ID:: 2KR6

View in iCn3D Proteins Conserved Domains

Select item 17011316.

Molecular Structure Image for 6IDF

Cryo-EM structure of gamma secretase in complex with a Notch fragment[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens

Proteins:: 5
Chemicals:: 28
modified:: 2019-01-28

MMDB ID:: 170113
PDB ID:: 6IDF

View in iCn3D Similar Structures PubMed Proteins Conserved Domains PubChem Compound

Select item 24771017.

Molecular Structure Image for 8X54

Cryo-EM structure of human gamma-secretase in complex with APP-C99[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens

Proteins:: 5
Chemicals:: 27
modified:: 2024-06-25

MMDB ID:: 247710
PDB ID:: 8X54

View in iCn3D Similar Structures PubMed Proteins PubChem Compound

Select item 24770918.

Molecular Structure Image for 8X53

Cryo-EM structure of human gamma-secretase in complex with Abeta46[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens

Proteins:: 5
Chemicals:: 26
modified:: 2024-06-25

MMDB ID:: 247709
PDB ID:: 8X53

View in iCn3D Similar Structures PubMed Proteins

Select item 24770819.

Molecular Structure Image for 8X52

Cryo-EM structure of human gamma-secretase in complex with Abeta49[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens

Proteins:: 5
Chemicals:: 25
modified:: 2024-06-25

MMDB ID:: 247708
PDB ID:: 8X52

View in iCn3D Similar Structures PubMed Proteins PubChem Compound

Select item 24579120.

Molecular Structure Image for 8OQZ

Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46[MEMBRANE PROTEIN]

Taxonomy:: Homo sapiens

Proteins:: 5
Chemicals:: 28
modified:: 2024-06-25

MMDB ID:: 245791
PDB ID:: 8OQZ

View in iCn3D Similar Structures PubMed Proteins PubChem Compound

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Protein Domain Families

Families (21)
Structures with functionally specific protein families
Superfamilies (32)
Structures with evolutionary related protein superfamilies

Complexes

Protein-Protein (39)
Structures containing multiple proteins
Protein-Chemical (24)
Structures containing proteins and chemicals

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Presenilin (53)
Structure
Immunobiology
Immunobiology
Streptomyces sp. 769 chromosome, complete genome
Streptomyces sp. 769 chromosome, complete genome
gi|749181963|ref|NZ_CP003987.1|

Nucleotide
fin bud initiation factor homolog precursor [Homo sapiens]
fin bud initiation factor homolog precursor [Homo sapiens]
gi|42766422|ref|NP_976249.1|

Protein
ATP-binding cassette sub-family A member 9 [Homo sapiens]
ATP-binding cassette sub-family A member 9 [Homo sapiens]
gi|27477115|ref|NP_525022.2|

Protein

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