8X54: Cryo-EM structure of human gamma-secretase in complex with APP-C99

PDB ID: 8X54Download
MMDB ID: 247710
PDB Deposition Date: 2023/11/16
Updated in MMDB: 2025/07
Experimental Method:
electron microscopy
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8X54: pentameric; determined by author
Molecular Components in 8X54
Label Count Molecule
Proteins (5 molecules)
1
Amyloid-beta Precursor Protein
(Gene symbol: APP)
Molecule annotation
1
Nicastrin
(Gene symbol: NCSTN)
Molecule annotation
1
Presenilin-1
(Gene symbol: PSEN1)
Molecule annotation
1
Gamma-secretase Subunit Aph-1a
(Gene symbol: APH1A)
Molecule annotation
1
Gamma-secretase Subunit Pen-2
(Gene symbol: PSENEN)
Molecule annotation
Chemicals and Non-standard biopolymers (27 molecules)
1
18
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
3
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
4
3
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303