8OQZ: Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46

PDB ID: 8OQZDownload
MMDB ID: 245791
PDB Deposition Date: 2023/4/12
Updated in MMDB: 2024/06
Experimental Method:
electron microscopy
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 8OQZ: pentameric; determined by author
Molecular Components in 8OQZ
Label Count Molecule
Proteins (5 molecules)
1
Nicastrin
(Gene symbol: NCSTN)
Molecule annotation
1
Presenilin-1 Ctf12
(Gene symbol: PSEN1)
Molecule annotation
1
Gamma-secretase Subunit Aph-1b
(Gene symbol: APH1B)
Molecule annotation
1
Gamma-secretase Subunit Pen-2
(Gene symbol: PSENEN)
Molecule annotation
1
Amyloid-beta Peptide 1-46
Molecule annotation
Chemicals and Non-standard biopolymers (28 molecules)
1
14
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
14
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303