PRE10 proteasome core particle subunit alpha 7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854544, updated on 5-May-2024

Download Datasets

Summary

Go to the top of the page Help

Gene symbol: PRE10
Gene description: proteasome core particle subunit alpha 7
Primary source: SGD:S000005889
Locus tag: YOR362C
See related: AllianceGenome:SGD:S000005889
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mRNA binding activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1017880..1018746, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteasome core particle subunit alpha 7 is a binding partner for Ecm29.Ecm29 requires the phosphorylated tail of the proteasome subunit alpha7 for its association with proteasomes.
Title: Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29.
the alpha7 N terminus of 20S proteasome has a role in core particle activation different from that of the alpha3 N terminus, and Fub1 antagonizes a specific function of the alpha7 N terminus
Title: N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function.
Data show that proteasome subunits Rpt1, Rpt4, Rpn8, Rpn12, Pre6, and Pre10 are recruited to GAL10 rapidly upon galactose induction.
Title: Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
located_in proteasome storage granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: proteasome core particle subunit alpha 7

NP_015007.1

Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1017880..1018746 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183782.1 → NP_015007.1 TPA: proteasome core particle subunit alpha 7 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015007.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W357, P21242

UniProtKB/TrEMBL

A0A6A5Q4M4, A6ZPJ2, B3LK19, C7GNQ6, C8ZHB0, G2WNM3, N1NXJ2

Conserved Domains (1) summary

cd03751
Location:5 → 219

proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
3JCO_G.1
3JCO_g.1
3JCP_G.1
3JCP_g.1
3UN4_F.1
3UN4_T.1
3UN8_F.1
3UN8_T.1
4G4S_G.1
4JSQ_F.1
4JSQ_T.1
4JSU_F.1
4JSU_T.1
4JT0_F.1
4JT0_T.1
4NNN_F.1
4NNN_T.1
4NNW_F.1
4NNW_T.1
4NO1_F.1
4NO1_T.1
4NO6_F.1
4NO6_T.1
4NO8_F.1
4NO8_T.1
4NO9_F.1
4NO9_T.1
4Q1S_F.1
4Q1S_T.1
4QBY_F.1
4QBY_T.1
4QLQ_F.1
4QLQ_T.1
4QLS_F.1
4QLS_T.1
4QLT_F.1
4QLT_T.1
4QLU_F.1
4QLU_T.1
4QLV_F.1
4QLV_T.1
4QUX_F.1
4QUX_T.1
4QUY_F.1
4QUY_T.1
4QV0_F.1
4QV0_T.1
4QV1_F.1
4QV1_T.1
4QV3_F.1
4QV3_T.1
4QV4_F.1
4QV4_T.1
4QV5_F.1
4QV5_T.1
4QV6_F.1
4QV6_T.1
4QV7_F.1
4QV7_T.1
4QV8_F.1
4QV8_T.1
4QV9_F.1
4QV9_T.1
4QVL_F.1
4QVL_T.1
4QVM_F.1
4QVM_T.1
4QVN_F.1
4QVN_T.1
4QVP_F.1
4QVP_T.1
4QVQ_F.1
4QVQ_T.1
4QVV_F.1
4QVV_T.1
4QVW_F.1
4QVW_T.1
4QVY_F.1
4QVY_T.1
4QW0_F.1
4QW0_T.1
4QW1_F.1
4QW1_T.1
4QW3_F.1
4QW3_T.1
4QW4_F.1
4QW4_T.1
4QW5_F.1
4QW5_T.1
4QW6_F.1
4QW6_T.1
4QW7_F.1
4QW7_T.1
4QWF_F.1
4QWF_T.1
4QWG_F.1
4QWG_T.1
4QWI_F.1
4QWI_T.1
4QWJ_F.1
4QWJ_T.1
4QWK_F.1
4QWK_T.1
4QWL_F.1
4QWL_T.1
4QWR_F.1
4QWR_T.1
4QWS_F.1
4QWS_T.1
4QWU_F.1
4QWU_T.1
4QWX_F.1
4QWX_T.1
4QXJ_F.1
4QXJ_T.1
4QZ0_F.1
4QZ0_T.1
4QZ1_F.1
4QZ1_T.1
4QZ2_F.1
4QZ2_T.1
4QZ3_F.1
4QZ3_T.1
4QZ4_F.1
4QZ4_T.1
4QZ5_F.1
4QZ5_T.1
4QZ6_F.1
4QZ6_T.1
4QZ7_F.1
4QZ7_T.1
4QZW_F.1
4QZW_T.1
4QZX_F.1
4QZX_T.1
4QZZ_F.1
4QZZ_T.1
4R00_F.1
4R00_T.1
4R02_F.1
4R02_T.1
4R17_F.1
4R17_T.1
4R18_F.1
4R18_T.1
4RUR_F.1
4RUR_T.1
4X6Z_G.1
4X6Z_U.1
4Y69_F.1
4Y69_T.1
4Y6A_F.1
4Y6A_T.1
4Y6V_F.1
4Y6V_T.1
4Y6Z_F.1
4Y6Z_T.1
4Y70_F.1
4Y70_T.1
4Y74_F.1
4Y74_T.1
4Y75_F.1
4Y75_T.1
4Y77_F.1
4Y77_T.1
4Y78_F.1
4Y78_T.1
4Y7W_F.1
4Y7W_T.1
4Y7X_F.1
4Y7X_T.1
4Y7Y_F.1
4Y7Y_T.1
4Y80_F.1
4Y80_T.1
4Y81_F.1
4Y81_T.1
4Y82_F.1
4Y82_T.1
4Y84_F.1
4Y84_T.1
4Y8G_F.1
4Y8G_T.1
4Y8H_F.1
4Y8H_T.1
4Y8I_F.1
4Y8I_T.1
4Y8J_F.1
4Y8J_T.1
4Y8K_F.1
4Y8K_T.1
4Y8L_F.1
4Y8L_T.1
4Y8M_F.1
4Y8M_T.1
4Y8N_F.1
4Y8N_T.1
4Y8O_F.1
4Y8O_T.1
4Y8P_F.1
4Y8P_T.1
4Y8Q_F.1
4Y8Q_T.1
4Y8R_F.1
4Y8R_T.1
4Y8S_F.1
4Y8S_T.1
4Y8T_F.1
4Y8T_T.1
4Y8U_F.1
4Y8U_T.1
4Y9Y_F.1
4Y9Y_T.1
4Y9Z_F.1
4Y9Z_T.1
4YA0_F.1
4YA0_T.1
4YA1_F.1
4YA1_T.1
4YA2_F.1
4YA2_T.1
4YA3_F.1
4YA3_T.1
4YA4_F.1
4YA4_T.1
4YA5_F.1
4YA5_T.1
4YA7_F.1
4YA7_T.1
4YA9_F.1
4YA9_T.1
4Z1L_F.1
4Z1L_T.1
5BOU_F.1
5BOU_T.1
5BXL_F.1
5BXL_T.1
5BXN_F.1
5BXN_T.1
5CGF_F.1
5CGF_T.1
5CGG_F.1
5CGG_T.1
5CGH_F.1
5CGH_T.1
5CGI_F.1
5CGI_T.1
5CZ4_F.1
5CZ4_T.1
5CZ5_F.1
5CZ5_T.1
5CZ6_F.1
5CZ6_T.1
5CZ7_F.1
5CZ7_T.1
5CZ8_F.1
5CZ8_T.1
5CZ9_F.1
5CZ9_T.1
5CZA_F.1
5CZA_T.1
5D0S_F.1
5D0S_T.1
5D0T_F.1
5D0T_T.1
5D0V_F.1
5D0V_T.1
5D0W_F.1
5D0W_T.1
5D0X_F.1
5D0X_T.1
5D0Z_F.1
5D0Z_T.1
5DKI_F.1
5DKI_T.1
5DKJ_F.1
5DKJ_T.1
5FG7_F.1
5FG7_T.1
5FG9_F.1
5FG9_T.1
5FGA_F.1
5FGA_T.1
5FGD_F.1
5FGD_T.1
5FGE_F.1
5FGE_T.1
5FGF_F.1
5FGF_T.1
5FGG_F.1
5FGG_T.1
5FGH_F.1
5FGH_T.1
5FGI_F.1
5FGI_T.1
5FHS_F.1
5FHS_T.1
5JHR_F.1
5JHR_T.1
5JHS_F.1
5JHS_T.1
5L52_F.1
5L52_T.1
5L54_F.1
5L54_T.1
5L55_F.1
5L55_T.1
5L5A_F.1
5L5A_T.1
5L5B_F.1
5L5B_T.1
5L5D_F.1
5L5D_T.1
5L5E_F.1
5L5E_T.1
5L5F_F.1
5L5F_T.1
5L5H_F.1
5L5H_T.1
5L5I_F.1
5L5I_T.1
5L5J_F.1
5L5J_T.1
5L5O_F.1
5L5O_T.1
5L5P_F.1
5L5P_T.1
5L5Q_F.1
5L5Q_T.1
5L5R_F.1
5L5R_T.1
5L5S_F.1
5L5S_T.1
5L5T_F.1
5L5T_T.1
5L5U_F.1
5L5U_T.1
5L5V_F.1
5L5V_T.1
5L5W_F.1
5L5W_T.1
5L5X_F.1
5L5X_T.1
5L5Y_F.1
5L5Y_T.1
5L5Z_F.1
5L5Z_T.1
5L60_F.1
5L60_T.1
5L61_F.1
5L61_T.1
5L62_F.1
5L62_T.1
5L63_F.1
5L63_T.1
5L64_F.1
5L64_T.1
5L65_F.1
5L65_T.1
5L66_F.1
5L66_T.1
5L67_F.1
5L67_T.1
5L68_F.1
5L68_T.1
5L69_F.1
5L69_T.1
5L6A_F.1
5L6A_T.1
5L6B_F.1
5L6B_T.1
5L6C_F.1
5L6C_T.1
5LAI_F.1
5LAI_T.1
5LAJ_F.1
5LAJ_T.1
5LTT_F.1
5LTT_T.1
5M2B_F.1
5M2B_T.1
5MP9_G.1
5MP9_g.1
5MPA_G.1
5MPA_g.1
5MPB_G.1
5MPB_g.1
5MPC_G.1
5MPC_g.1
5NIF_G.1
5NIF_U.1
5WVI_G.1
5WVI_k.1
5WVK_G.1
5WVK_k.1
6EF3_G.1
6G7F_F.1
6G7F_T.1
6G8M_F.1
6G8M_T.1
6G8N_F.1
6G8N_T.1
6GOP_F.1
6GOP_T.1
6H39_F.1
6H39_T.1
6HTB_F.1
6HTB_T.1
6HTC_F.1
6HTC_T.1
6HTD_F.1
6HTD_T.1
6HTP_F.1
6HTP_T.1
6HTR_F.1
6HTR_T.1
6HUB_F.1
6HUB_T.1
6HUC_F.1
6HUC_T.1
6HUQ_F.1
6HUQ_T.1
6HUU_F.1
6HUU_T.1
6HUV_F.1
6HUV_T.1
6HV3_F.1
6HV3_T.1
6HV4_F.1
6HV4_T.1
6HV5_F.1
6HV5_T.1
6HV7_F.1
6HV7_T.1
6HVA_F.1
6HVA_T.1
6HVR_F.1
6HVR_T.1
6HVS_F.1
6HVS_T.1
6HVT_F.1
6HVT_T.1
6HVU_F.1
6HVU_T.1
6HVV_F.1
6HVV_T.1
6HVW_F.1
6HVW_T.1
6HVX_F.1
6HVX_T.1
6HVY_F.1
6HVY_T.1
6HW0_F.1
6HW0_T.1
6HW3_F.1
6HW3_T.1
6HW4_F.1
6HW4_T.1
6HW5_F.1
6HW5_T.1
6HW6_F.1
6HW6_T.1
6HW7_F.1
6HW7_T.1
6HW8_F.1
6HW8_T.1
6HW9_F.1
6HW9_T.1
6HWA_F.1
6HWA_T.1
6HWB_F.1
6HWB_T.1
6HWC_F.1
6HWC_T.1
6HWD_F.1
6HWD_T.1
6HWE_F.1
6HWE_T.1
6HWF_F.1
6HWF_T.1
6J2C_G.1
6J2C_k.1
6J2N_G.1
6J2N_k.1
6J2Q_G.1
6J2Q_k.1
6J2X_G.1
6J2X_k.1
6J30_G.1
6J30_k.1
6ZOU_F.1
6ZOU_T.1
6ZP6_F.1
6ZP6_T.1
6ZP8_F.1
6ZP8_T.1
7LS5_G.1
7LS5_U.1
7LS6_G.1
7LSX_G.1
P21242.2