SOD1 superoxide dismutase SOD1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SOD1
Official Full Name: superoxide dismutase SOD1
Primary source: SGD:S000003865
Locus tag: YJR104C
See related: AllianceGenome:SGD:S000003865; FungiDB:YJR104C; VEuPathDB:YJR104C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CRS4
Summary: Enables superoxide dismutase activity. Involved in several processes, including cellular transition metal ion homeostasis; protein stabilization; and regulation of transcription, DNA-templated. Located in cytosol; mitochondrial intermembrane space; and nucleus. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (622550..623014, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOD1 mutations cause hypersensitivity to high-pressure-induced oxidative stress in Saccharomyces cerevisiae.
Title: SOD1 mutations cause hypersensitivity to high-pressure-induced oxidative stress in Saccharomyces cerevisiae.
SOD1 is an essential H2S detoxifying enzyme.
Title: SOD1 is an essential H(2)S detoxifying enzyme.
Meiotic resetting of the cellular Sod1 pool is driven by protein aggregation, degradation, and transient LUTI-mediated repression.
Title: Meiotic resetting of the cellular Sod1 pool is driven by protein aggregation, degradation, and transient LUTI-mediated repression.
Unbalance between Pyridine Nucleotide Cofactors in The SOD1 Deficient Yeast Saccharomyces cerevisiae Causes Hypersensitivity to Alcohols and Aldehydes.
Title: Unbalance between Pyridine Nucleotide Cofactors in The SOD1 Deficient Yeast Saccharomyces cerevisiae Causes Hypersensitivity to Alcohols and Aldehydes.
Linkage between Carbon Metabolism, Redox Status and Cellular Physiology in the Yeast Saccharomyces cerevisiae Devoid of SOD1 or SOD2 Gene.
Title: Linkage between Carbon Metabolism, Redox Status and Cellular Physiology in the Yeast Saccharomyces cerevisiae Devoid of SOD1 or SOD2 Gene.
Genetic Variation in Complex Traits in Transgenic alpha-Synuclein Strains of Caenorhabditis elegans.
Title: Genetic Variation in Complex Traits in Transgenic α-Synuclein Strains of Caenorhabditis elegans.
Lack of SOD1 in a RAD51 mutant depending on CCS1 exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae.
Title: Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae.
Cu(I) is transferred from CCS1 to the entry site and then to the SOD1 active site by a thermodynamically driven affinity gradient.
Title: The yeast copper chaperone for copper-zinc superoxide dismutase (CCS1) is a multifunctional chaperone promoting all levels of SOD1 maturation.
propose a model in which Sod1p maximizes Pma1p activity in two ways: one involving signaling through CK1gamma casein kinases and an independent role for Sod1p in oxidative stress protection
Title: Cu/Zn superoxide dismutase and the proton ATPase Pma1p of Saccharomyces cerevisiae.
Data indicate that the role of Zn in Cu,Zn-superoxide dismutase SOD1 is structural and also a vital part of the catalytic machinery.
Title: Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IPI Inferred from Physical Interaction more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in superoxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: superoxide dismutase SOD1

NP_012638.1

EC 1.15.1.1

Cytosolic copper-zinc superoxide dismutase; also sulfide oxidase; detoxifies superoxide and hydrogen sulfide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; abundance increases under DNA replication stress; localization to mitochondrial intermembrane space is modulated by MICOS complex; human ortholog SOD1 implicated in ALS complements a null allele

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

622550..623014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181762.1 → NP_012638.1 TPA: superoxide dismutase SOD1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012638.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWS3, P00445, Q68HB2

UniProtKB/TrEMBL

A6ZQ60, C7GMA4, C8ZBQ1, G2WHA7, N1P179

Conserved Domains (1) summary

pfam00080
Location:14 → 149

Sod_Cu; Copper/zinc superoxide dismutase (SODC)