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    Mtch1 mitochondrial carrier 1 [ Mus musculus (house mouse) ]

    Gene ID: 56462, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mtch1provided by MGI
    Official Full Name
    mitochondrial carrier 1provided by MGI
    Primary source
    MGI:MGI:1929261
    See related
    Ensembl:ENSMUSG00000024012 AllianceGenome:MGI:1929261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSAP; 2310034O17Rik
    Summary
    Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process. Located in mitochondrion. Is expressed in cerebral cortex marginal layer; choroid invagination; diencephalon roof plate; metencephalon part of 4th ventricle choroid plexus; and thyroid gland. Orthologous to human MTCH1 (mitochondrial carrier 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 154.2), genital fat pad adult (RPKM 153.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 15.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29551050..29566921, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29332076..29347947, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 10045 Neighboring gene predicted gene, 46603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29469332-29469441 Neighboring gene peptidase inhibitor 16 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29475389-29475661 Neighboring gene STARR-positive B cell enhancer ABC_E4202 Neighboring gene STARR-positive B cell enhancer ABC_E5586 Neighboring gene STARR-positive B cell enhancer ABC_E7508 Neighboring gene FYVE, RhoGEF and PH domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10944 Neighboring gene STARR-seq mESC enhancer starr_42277 Neighboring gene STARR-seq mESC enhancer starr_42278 Neighboring gene STARR-positive B cell enhancer ABC_E2478 Neighboring gene STARR-positive B cell enhancer ABC_E8664 Neighboring gene VISTA enhancer mm81 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29574287-29574588 Neighboring gene predicted gene, 36486 Neighboring gene predicted gene, 36199

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP. Mao G, et al. Biochim Biophys Acta, 2008 Apr. PMID 18291114, Free PMC Article
    2. The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development. Nacarino-Palma A, et al. Stem Cell Reports, 2021 Sep 14. PMID 34478649, Free PMC Article
    3. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial carrier homolog 1
    Names
    mitochondrial carrier-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347335.1 → NP_001334264.1  mitochondrial carrier homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162182, CD740861
      Consensus CDS
      CCDS84288.1
      UniProtKB/Swiss-Prot
      Q791T5
      Related
      ENSMUSP00000113021.2, ENSMUST00000118366.9
      Conserved Domains (1) summary
      pfam00153
      Location:206 → 264
      Mito_carr; Mitochondrial carrier protein

    2. NM_001357762.1 → NP_001344691.1  mitochondrial carrier homolog 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA215277, AC162182
      Consensus CDS
      CCDS89048.1
      UniProtKB/TrEMBL
      A0A3Q4EBT8, A0A3Q4EC24
      Related
      ENSMUSP00000157010.2, ENSMUST00000234507.2
      Conserved Domains (1) summary
      pfam00153
      Location:94 → 152
      Mito_carr; Mitochondrial carrier protein

    3. NM_001357763.1 → NP_001344692.1  mitochondrial carrier homolog 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA215277, AC162182
      Consensus CDS
      CCDS89049.1
      UniProtKB/TrEMBL
      A0A3Q4EG99, D3YXC2
      Related
      ENSMUSP00000157094.2, ENSMUST00000235088.2
      Conserved Domains (1) summary
      pfam00153
      Location:94 → 152
      Mito_carr; Mitochondrial carrier protein

    4. NM_019880.4 → NP_063933.1  mitochondrial carrier homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_063933.1

      Status: VALIDATED

      Source sequence(s)
      AC162182
      Consensus CDS
      CCDS28596.1
      UniProtKB/Swiss-Prot
      Q3U4W7, Q791T5, Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4
      Related
      ENSMUSP00000093077.5, ENSMUST00000095427.12
      Conserved Domains (1) summary
      pfam00153
      Location:206 → 264
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29551050..29566921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524668.2 → XP_006524731.1  mitochondrial carrier homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006524731.1

      UniProtKB/Swiss-Prot
      Q3U4W7, Q791T5, Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4
      Conserved Domains (1) summary
      pfam00153
      Location:206 → 264
      Mito_carr; Mitochondrial carrier protein

    2. XM_006524670.3 → XP_006524733.1  mitochondrial carrier homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006524733.1

      UniProtKB/Swiss-Prot
      Q791T5
      Conserved Domains (1) summary
      pfam00153
      Location:206 → 264
      Mito_carr; Mitochondrial carrier protein

    3. XM_036160691.1 → XP_036016584.1  mitochondrial carrier homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q4EBT8, A0A3Q4EC24
      Related
      ENSMUSP00000157218.2, ENSMUST00000235021.2
      Conserved Domains (1) summary
      pfam00153
      Location:94 → 152
      Mito_carr; Mitochondrial carrier protein

    4. XM_030249918.2 → XP_030105778.1  mitochondrial carrier homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q4EG99, D3YXC2
      Related
      ENSMUSP00000115027.3, ENSMUST00000153658.3
      Conserved Domains (1) summary
      pfam00153
      Location:94 → 152
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q791T5.1 GenPept UniProtKB/Swiss-Prot:Q791T5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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