Abl Abl tyrosine kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ablprovided by FlyBase
Official Full Name: Abl tyrosine kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0000017
Locus tag: Dmel_CG4032
See related: AllianceGenome:FB:FBgn0000017
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4674; abl; ABL; abl1; Abl1; Ableson; AblK; Am ABL; c-abl; C-abl; cAbl; CG4032; D-abl; D-Abl; D-ash; dAbl; Dabl; DAbl; Dash; Ddash/abl; Dmel\CG4032; DROTKABL3; Dsrc7; l(3)04674; l(3)73Ba; l(3)c-abl
Summary: Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including cell morphogenesis involved in differentiation; protein phosphorylation; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including apical cortex; cell-cell junction; and muscle tendon junction. Is extrinsic component of plasma membrane. Colocalizes with contractile ring. Is expressed in several structures, including adepithelial cell; adult brain; ovary; photoreceptor cell; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 73B1-73B4; 3-44 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16615866..16647882, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16608966..16640982, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
Title: The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.
Title: Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.
Htt is a repressor of Abl activity required for APP-induced axonal growth.
Title: Htt is a repressor of Abl activity required for APP-induced axonal growth.
Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions.
Title: Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions.
Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin.
Title: Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin.
Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase.
Title: Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase.
BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
Title: BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis.
Notch-Abl axonal signaling requires proteolytic cleavage events that initiate canonical Notch signaling. Some Notch protein is tyrosine phosphorylated, this form of the protein is selectively associated with Disabled and Trio, and relevant tyrosines are essential for Notch-dependent axon patterning but not for canonical Notch-dependent regulation of cell fate.
Title: Tyrosine phosphorylation and proteolytic cleavage of Notch are required for non-canonical Notch/Abl signaling in Drosophila axon guidance.
The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase.
Title: The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.
In conjunction with its receptor Neurotactin (Nrt) and the effector kinase Abelson tyrosine kinase (Abl), Ama is necessary in parallel to the cell-autonomous Dfd pathway for the correct specification of the maxillary identity of NB6-4
Title: Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branchiomotor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin polymerization or depolymerization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with contractile ring	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Abl tyrosine kinase

Names: Abl oncogene; Abl-PA; Abl-PB; Abl-PC; Abl-PD; Abl-PE; Abl-PF; Abl-PG; Abl-PH; Abl-PI; Abl-PJ; CG4032-PA; CG4032-PB; CG4032-PC; CG4032-PD; CG4032-PE; CG4032-PF; CG4032-PG; CG4032-PH; CG4032-PI; CG4032-PJ; D-abelson; abelson; abelson kinase; abelson tyrosine kinase; abl kinase

NP_001097623.1

EC 2.7.10.2

NP_001261959.1

EC 2.7.10.2

NP_001261960.1

EC 2.7.10.2

NP_001261961.1

EC 2.7.10.2

NP_001261962.1

EC 2.7.10.2

NP_001261963.1

EC 2.7.10.2

NP_001261964.1

EC 2.7.10.2

NP_001261965.1

EC 2.7.10.2

NP_001287085.1

EC 2.7.10.2

NP_524843.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

16615866..16647882 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300156.1 → NP_001287085.1 Abl tyrosine kinase, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287085.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P00522, Q95TV1, Q9VV86

UniProtKB/TrEMBL

X2JGR4

Conserved Domains (5) summary

smart00808
Location:1481 → 1620

FABD; F-actin binding domain (FABD)

cd09935
Location:250 → 345

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:191 → 245

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:364 → 626

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:371 → 622

Pkinase_Tyr; Protein tyrosine kinase
NM_001104153.3 → NP_001097623.1 Abl tyrosine kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097623.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNU2

Conserved Domains (5) summary

smart00808
Location:1499 → 1638

FABD; F-actin binding domain (FABD)

cd09935
Location:268 → 363

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:209 → 263

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:382 → 644

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:389 → 640

Pkinase_Tyr; Protein tyrosine kinase
NM_001275035.1 → NP_001261964.1 Abl tyrosine kinase, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261964.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCU1

Conserved Domains (5) summary

smart00808
Location:1365 → 1504

FABD; F-actin binding domain (FABD)

cd09935
Location:250 → 345

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:191 → 245

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:364 → 626

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:371 → 622

Pkinase_Tyr; Protein tyrosine kinase
NM_080104.3 → NP_524843.2 Abl tyrosine kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524843.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P00522, Q95TV1, Q9VV86

UniProtKB/TrEMBL

X2JGR4

Related

FBpp0075116

Conserved Domains (5) summary

smart00808
Location:1481 → 1620

FABD; F-actin binding domain (FABD)

cd09935
Location:250 → 345

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:191 → 245

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:364 → 626

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:371 → 622

Pkinase_Tyr; Protein tyrosine kinase
NM_001275032.1 → NP_001261961.1 Abl tyrosine kinase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261961.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFX0

Conserved Domains (5) summary

smart00808
Location:1450 → 1589

FABD; F-actin binding domain (FABD)

cd09935
Location:250 → 345

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:191 → 245

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:364 → 626

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:371 → 622

Pkinase_Tyr; Protein tyrosine kinase
NM_001275030.1 → NP_001261959.1 Abl tyrosine kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261959.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCT8

Conserved Domains (5) summary

smart00808
Location:1566 → 1705

FABD; F-actin binding domain (FABD)

cd09935
Location:250 → 345

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:191 → 245

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:364 → 626

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:371 → 622

Pkinase_Tyr; Protein tyrosine kinase
NM_001275034.1 → NP_001261963.1 Abl tyrosine kinase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261963.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PI83

Conserved Domains (5) summary

smart00808
Location:1383 → 1522

FABD; F-actin binding domain (FABD)

cd09935
Location:268 → 363

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:209 → 263

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:382 → 644

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:389 → 640

Pkinase_Tyr; Protein tyrosine kinase
NM_001275036.1 → NP_001261965.1 Abl tyrosine kinase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261965.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFI8

Conserved Domains (5) summary

smart00808
Location:1499 → 1638

FABD; F-actin binding domain (FABD)

cd09935
Location:268 → 363

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:209 → 263

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:382 → 644

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:389 → 640

Pkinase_Tyr; Protein tyrosine kinase
NM_001275031.1 → NP_001261960.1 Abl tyrosine kinase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261960.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFI5

Conserved Domains (5) summary

smart00808
Location:1468 → 1607

FABD; F-actin binding domain (FABD)

cd09935
Location:268 → 363

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:209 → 263

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:382 → 644

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:389 → 640

Pkinase_Tyr; Protein tyrosine kinase
NM_001275033.1 → NP_001261962.1 Abl tyrosine kinase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261962.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFS1

Conserved Domains (5) summary

smart00808
Location:1584 → 1723

FABD; F-actin binding domain (FABD)

cd09935
Location:268 → 363

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:209 → 263

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:382 → 644

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:389 → 640

Pkinase_Tyr; Protein tyrosine kinase

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A8JNU2		A8JNU2
M9PCT8		M9PCT8
M9PCU1		M9PCU1
M9PFI5		M9PFI5
M9PFI8		M9PFI8
M9PFS1		M9PFS1
M9PFX0		M9PFX0
M9PI83		M9PI83
P00522.3		P00522
X2JGR4		X2JGR4