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    Plekhg2 pleckstrin homology and RhoGEF domain containing G2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292750, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Plekhg2provided by RGD
    Official Full Name
    pleckstrin homology and RhoGEF domain containing G2provided by RGD
    Primary source
    RGD:1310112
    See related
    Ensembl:ENSRNOG00000030266 AllianceGenome:RGD:1310112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310112
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of actin filament polymerization. Orthologous to human PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 48.4), Spleen (RPKM 39.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92779449..92792610, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83651902..83665063, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85386492..85399699)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ribosomal protein S16 Neighboring gene transfer RNA isoleucine (anticodon UAU) 1 Neighboring gene zinc finger protein 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Microcephaly-dystonia due to mutated PLEKHG2 with impaired actin polymerization. Edvardson S, et al. Neurogenetics, 2016 Jan. PMID 26573021
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189384

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 2
    Names
    pleckstrin homology domain containing, family G (with RhoGef domain) member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134972.2 → NP_001128444.1  pleckstrin homology domain-containing family G member 2 isoform 2

      See identical proteins and their annotated locations for NP_001128444.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A1W2Q6B3, A6J9I5, G3V9A0
      Related
      ENSRNOP00000040619.3, ENSRNOT00000044326.4
      Conserved Domains (3) summary
      cd13243
      Location:259 → 409
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:333 → 405
      PH; PH domain
      pfam00621
      Location:102 → 278
      RhoGEF; RhoGEF domain

    2. NM_001415791.1 → NP_001402720.1  pleckstrin homology domain-containing family G member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000096483.1, ENSRNOT00000093265.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      92779449..92792610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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