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    Gnpat Glyceronephosphate O-acyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53586, updated on 19-Jun-2024

    Summary

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    Official Symbol
    Gnpatprovided by FlyBase
    Official Full Name
    Glyceronephosphate O-acyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040212
    Locus tag
    Dmel_CG4625
    See related
    AllianceGenome:FB:FBgn0040212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8-1; CG4625; Dhap-at; DHAP-AT; DHAPAT; Dmel\CG4625; GNPAT; Gpat; GPAT
    Summary
    Predicted to enable glycerone-phosphate O-acyltransferase activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to be located in peroxisomal membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Gnpat in Genome Data Viewer
    Location:
    96E2-96E2; 3-88 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25485618..25490936, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21311340..21316658, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene XNP Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44179 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Santoro C, et al. Sci Rep, 2022 Jul 29. PMID 35906462, Free PMC Article
    2. Ecdysone and insulin signaling play essential roles in readjusting the altered body size caused by the dGPAT4 mutation in Drosophila. Yan Y, et al. J Genet Genomics, 2015 Sep 20. PMID 26408093
    3. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Seegmiller AC, et al. Dev Cell, 2002 Feb. PMID 11832248
    4. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Kim GH, et al. Biochem Biophys Res Commun, 2015 Jan 9. PMID 25511696
    5. Conditioned courtship suppression in Drosophila melanogaster. Raun N, et al. J Neurogenet, 2021 Sep. PMID 33522326

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ether lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ether lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ether lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glyceronephosphate O-acyltransferase
    Names
    CG4625-PA
    CG4625-PB
    CG4625-PC
    Gnpat-PA
    Gnpat-PB
    Gnpat-PC
    dihydroxyacetone phosphate acyltansferase
    dihydroxyacetone phosphate acyltransferase
    glycerol 3-phosphate acyltransferase
    glycerol-3-phosphate acyltransferase
    glycerol-3-phosphate-acyltransferase
    NP_001262956.1
    NP_001262957.1
    NP_525010.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25485618..25490936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080271.4 → NP_525010.1  glyceronephosphate O-acyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHF2, Q9VBQ6
      Related
      FBpp0084271
      Conserved Domains (1) summary
      cd07993
      Location:133 → 338
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    2. NM_001276028.1 → NP_001262957.1  glyceronephosphate O-acyltransferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262957.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHK0, Q9NHF2
      Conserved Domains (1) summary
      cd07993
      Location:133 → 338
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    3. NM_001276027.1 → NP_001262956.1  glyceronephosphate O-acyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHF2, Q9VBQ6
      Conserved Domains (1) summary
      cd07993
      Location:133 → 338
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHK0 A0A0B4KHK0
    Q95RN8 Q95RN8
    Q9NHF2 Q9NHF2
    Q9VBQ6 Q9VBQ6

    Gene LinkOut

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