Mcm5 Minichromosome maintenance 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mcm5provided by FlyBase
Official Full Name: Minichromosome maintenance 5provided by FlyBase
Primary source: FLYBASE:FBgn0017577
Locus tag: Dmel_CG4082
See related: AllianceGenome:FB:FBgn0017577
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4082; DmCDC46; DmCDC465; Dmel\CG4082; DmeMCM5; DmMcm5; DmMCM5; mcm5; McM5; MCM5; PCR4
Summary: Contributes to 3'-5' DNA helicase activity. Involved in DNA endoreduplication; chromosome condensation; and resolution of meiotic recombination intermediates. Part of CMG complex and MCM complex. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; extended germ band embryo; gonad; and ventral midline of embryo. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10788524..10791150)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6614246..6616872)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to 3'-5' DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in resolution of meiotic recombination intermediates	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CMG complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MCM complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

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