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    slgA sluggish A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33117, updated on 10-May-2024

    Summary

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    Official Symbol
    slgAprovided by FlyBase
    Official Full Name
    sluggish Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003423
    Locus tag
    Dmel_CG1417
    See related
    AllianceGenome:FB:FBgn0003423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1417; Dmel\CG1417; EE85; PRODH; sl; slg; tu3
    Summary
    Enables proline dehydrogenase activity. Involved in several processes, including aggressive behavior; phototaxis; and proline catabolic process. Located in mitochondrion. Is expressed in several structures, including LNv neurons; adult gnathal ganglion; anal pad; spermatozoon; and wing disc. Used to study schizophrenia. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to several human genes including PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See slgA in Genome Data Viewer
    Location:
    19F6-20A1; 1-66 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21374002..21385159)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21245029..21256186)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Septin 1 Neighboring gene waclaw Neighboring gene bobby sox Neighboring gene antisense RNA:CR45612 Neighboring gene antisense RNA:CR45611 Neighboring gene ncRNA Neighboring gene DEAD-box helicase 56 Neighboring gene misato

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurotransmitter levels and synaptic strength at the Drosophila larval neuromuscular junction are not altered by mutation in the sluggish-A gene, which encodes proline oxidase and affects adult locomotion. Shayan AJ, et al. J Neurogenet, 2000 Sep. PMID 10992167
    2. SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression. Zwarts L, et al. Dis Model Mech, 2017 Jun 1. PMID 28331058, Free PMC Article
    3. Cold tolerance and proline metabolic gene expression in Drosophila melanogaster. Misener SR, et al. J Insect Physiol, 2001 Apr. PMID 11166304
    4. Mechanism-based inhibition of proline dehydrogenase by proline analogues. Tritsch D, et al. Biochim Biophys Acta, 1993 Sep 3. PMID 8373828
    5. Behavioral analysis in Drosophila mosaics. Hall JC. Results Probl Cell Differ, 1978. PMID 749096

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. knockdown and overexpression of human PRODH and slgA in the lateral neurons ventral (LNv) lead to altered aggressive behavior.
      Title: SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proline dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proline catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sluggish A
    Names
    CG1417-PA
    CG1417-PB
    CG1417-PC
    CG1417-PD
    CG1417-PE
    CG1417-PF
    CG1417-PG
    CG1417-PH
    CG1417-PI
    CG1417-PJ
    CG1417-PK
    CG1417-PL
    CG1417-PM
    CG1417-PN
    proline dehydrogenase
    slgA-PA
    slgA-PB
    slgA-PC
    slgA-PD
    slgA-PE
    slgA-PF
    slgA-PG
    slgA-PH
    slgA-PI
    slgA-PJ
    slgA-PK
    slgA-PL
    slgA-PM
    slgA-PN
    sluggish
    sluggish-A
    sluggishA
    NP_001245791.1
    NP_001245792.1
    NP_001245793.1
    NP_001245794.1
    NP_001245795.1
    NP_001245796.1
    NP_523433.2
    NP_728422.1
    NP_728423.1
    NP_728424.1
    NP_728425.1
    NP_996526.1
    NP_996527.1
    NP_996528.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21374002..21385159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258863.2 → NP_001245792.1  sluggish A, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    2. NM_206803.3 → NP_996526.1  sluggish A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    3. NM_078709.4 → NP_523433.2  sluggish A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523433.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NHG9
      Related
      FBpp0076904
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 668
      PLN02681; proline dehydrogenase
      pfam01619
      Location:417 → 653
      Pro_dh; Proline dehydrogenase

    4. NM_167752.3 → NP_728423.1  sluggish A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728423.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61349, Q04499, Q8IQ45, Q8IQ46, Q8T0C7, Q9VRH7, Q9VRH8, Q9VRH9, Q9VRI2
      Related
      FBpp0076903
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 668
      PLN02681; proline dehydrogenase
      pfam01619
      Location:417 → 653
      Pro_dh; Proline dehydrogenase

    5. NM_167753.3 → NP_728424.1  sluggish A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFJ2
      Related
      FBpp0076905
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    6. NM_001258862.2 → NP_001245791.1  sluggish A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFJ2
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    7. NM_206805.3 → NP_996528.1  sluggish A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    8. NM_167751.3 → NP_728422.1  sluggish A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      Related
      FBpp0076902
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    9. NM_001258864.2 → NP_001245793.1  sluggish A, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    10. NM_001258867.2 → NP_001245796.1  sluggish A, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NHG9
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 668
      PLN02681; proline dehydrogenase
      pfam01619
      Location:417 → 653
      Pro_dh; Proline dehydrogenase

    11. NM_206804.3 → NP_996527.1  sluggish A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    12. NM_001258866.2 → NP_001245795.1  sluggish A, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFJ2
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    13. NM_001258865.2 → NP_001245794.1  sluggish A, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      Conserved Domains (2) summary
      PLN02681
      Location:93 → 656
      PLN02681; proline dehydrogenase
      pfam01619
      Location:405 → 641
      Pro_dh; Proline dehydrogenase

    14. NM_167754.2 → NP_728425.1  sluggish A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0076906
      Conserved Domains (1) summary
      pfam01619
      Location:92 → 328
      Pro_dh; Proline dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V4U5 A4V4U5
    M9NFJ2 M9NFJ2
    M9NHG9 M9NHG9
    Q04499.2 Q04499

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