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Multiple sclerosis

MedGen UID:
10123
Concept ID:
C0026769
Disease or Syndrome
Synonyms: Disseminated Sclerosis; MS (Multiple Sclerosis); Multiple Sclerosis; Sclerosis, Disseminated; Sclerosis, Multiple
SNOMED CT: Disseminated sclerosis (24700007); MS - Multiple sclerosis (24700007); DS - Disseminated sclerosis (24700007); Multiple sclerosis (24700007)
 
Monarch Initiative: MONDO:0005301

Definition

A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers. [from NCI]

Recent clinical studies

Etiology

Leguy S, Lefort M, Lescot L, Michaud A, Vukusic S, Le Page E, Edan G, Kerbrat A, Lebrun-Frenay C, De Sèze J, Laplaud DA, Wiertlewski S, Leray E, Michel L
J Neurol 2022 Oct;269(10):5571-5581. Epub 2022 Jun 23 doi: 10.1007/s00415-022-11215-7. PMID: 35737108
Bergamaschi R, Beghi E, Bosetti C, Ponzio M, Santucci C, Lepore V, Mosconi P; Italian Multiple Sclerosis and Related Disorders Register Centers Group and the Scientific Committee of Italian SM and Related Disorders Register., Aguglia U, Amato MP, Ancona AL, Ardito B, Avolio C, Balgera R, Banfi P, Barcella V, Barone P, Bellantonio P, Berardinelli A, Bergamaschi R, Bertora P, Bianchi M, Bramanti P, Morra VB, Brichetto G, Brioschi AM, Buccafusca M, Bucello S, Busillo V, Calchetti B, Cantello R, Capobianco M, Capone F, Capone L, Cargnelutti D, Carrozzi M, Cartechini E, Cavaletti G, Cavalla P, Celani MG, Clerici R, Clerico M, Cocco E, Confalonieri P, Coniglio MG, Conte A, Corea F, Cottone S, Crociani P, D'Andrea F, Danni MC, De Luca G, de Pascalis D, De Riz M, De Robertis F, De Rosa G, De Stefano N, Corte MD, Di Sapio A, Docimo R, Falcini M, Falcone N, Fermi S, Ferraro E, Ferrò MT, Fortunato M, Foschi M, Gajofatto A, Gallo A, Gallo P, Gatto M, Gazzola P, Giordano A, Granella F, Grasso MF, Grasso MG, Grimaldi LME, Iaffaldano P, Imperiale D, Inglese M, Iodice R, Leva S, Luezzi V, Lugaresi A, Lus G, Maimone D, Mancinelli L, Maniscalco GT, Marfia GA, Marini B, Marson A, Mascoli N, Massacesi L, Melani F, Merello M, Meucci G, Mirabella M, Montepietra S, Nasuelli D, Nicolao P, Passantino F, Patti F, Peresson M, Pesci I, Piantadosi C, Piras ML, Pizzorno M, Plewnia K, Pozzilli C, Protti A, Quatrale R, Realmuto S, Ribizzi G, Rinalduzzi S, Rini A, Romano S, Romeo M, Ronzoni M, Rossi P, Rovaris M, Salemi G, Santangelo G, Santangelo M, Santuccio G, Sarchielli P, Sinisi L, Sola P, Solaro C, Spitaleri D, Strumia S, Tassinari T, Tonietti S, Tortorella C, Totaro R, Tozzo A, Trivelli G, Ulivelli M, Valentino P, Venturi S, Vianello M, Zaffaroni M, Zarbo R, Trojano M, Battaglia MA, Capobianco M, Pugliatti M, Ulivelli M, Mosconi P, Gasperini C, Patti F, Amato MP, Bergamaschi R, Comi G
Neurol Sci 2022 Sep;43(9):5459-5469. Epub 2022 Jun 7 doi: 10.1007/s10072-022-06169-7. PMID: 35672479Free PMC Article
Margoni M, Pagani E, Meani A, Storelli L, Mesaros S, Drulovic J, Barkhof F, Vrenken H, Strijbis E, Gallo A, Bisecco A, Pareto D, Sastre-Garriga J, Ciccarelli O, Yiannakas M, Palace J, Preziosa P, Rocca MA, Filippi M; MAGNIMS Study Group.
J Neurol Neurosurg Psychiatry 2022 Jul;93(7):741-752. Epub 2022 May 17 doi: 10.1136/jnnp-2022-328908. PMID: 35580993
Bossart J, Kamm CP, Kaufmann M, Stanikić M, Puhan MA, Kesselring J, Zecca C, Gobbi C, Rapold I, Kurmann R, Ammann S, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).
Mult Scler Relat Disord 2022 Apr;60:103706. Epub 2022 Feb 21 doi: 10.1016/j.msard.2022.103706. PMID: 35228114
Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive PH, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg H, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle J; NfL Reference Database in the Swiss Multiple Sclerosis Cohort Study Group.
Lancet Neurol 2022 Mar;21(3):246-257. doi: 10.1016/S1474-4422(22)00009-6. PMID: 35182510

Diagnosis

Bergamaschi R, Beghi E, Bosetti C, Ponzio M, Santucci C, Lepore V, Mosconi P; Italian Multiple Sclerosis and Related Disorders Register Centers Group and the Scientific Committee of Italian SM and Related Disorders Register., Aguglia U, Amato MP, Ancona AL, Ardito B, Avolio C, Balgera R, Banfi P, Barcella V, Barone P, Bellantonio P, Berardinelli A, Bergamaschi R, Bertora P, Bianchi M, Bramanti P, Morra VB, Brichetto G, Brioschi AM, Buccafusca M, Bucello S, Busillo V, Calchetti B, Cantello R, Capobianco M, Capone F, Capone L, Cargnelutti D, Carrozzi M, Cartechini E, Cavaletti G, Cavalla P, Celani MG, Clerici R, Clerico M, Cocco E, Confalonieri P, Coniglio MG, Conte A, Corea F, Cottone S, Crociani P, D'Andrea F, Danni MC, De Luca G, de Pascalis D, De Riz M, De Robertis F, De Rosa G, De Stefano N, Corte MD, Di Sapio A, Docimo R, Falcini M, Falcone N, Fermi S, Ferraro E, Ferrò MT, Fortunato M, Foschi M, Gajofatto A, Gallo A, Gallo P, Gatto M, Gazzola P, Giordano A, Granella F, Grasso MF, Grasso MG, Grimaldi LME, Iaffaldano P, Imperiale D, Inglese M, Iodice R, Leva S, Luezzi V, Lugaresi A, Lus G, Maimone D, Mancinelli L, Maniscalco GT, Marfia GA, Marini B, Marson A, Mascoli N, Massacesi L, Melani F, Merello M, Meucci G, Mirabella M, Montepietra S, Nasuelli D, Nicolao P, Passantino F, Patti F, Peresson M, Pesci I, Piantadosi C, Piras ML, Pizzorno M, Plewnia K, Pozzilli C, Protti A, Quatrale R, Realmuto S, Ribizzi G, Rinalduzzi S, Rini A, Romano S, Romeo M, Ronzoni M, Rossi P, Rovaris M, Salemi G, Santangelo G, Santangelo M, Santuccio G, Sarchielli P, Sinisi L, Sola P, Solaro C, Spitaleri D, Strumia S, Tassinari T, Tonietti S, Tortorella C, Totaro R, Tozzo A, Trivelli G, Ulivelli M, Valentino P, Venturi S, Vianello M, Zaffaroni M, Zarbo R, Trojano M, Battaglia MA, Capobianco M, Pugliatti M, Ulivelli M, Mosconi P, Gasperini C, Patti F, Amato MP, Bergamaschi R, Comi G
Neurol Sci 2022 Sep;43(9):5459-5469. Epub 2022 Jun 7 doi: 10.1007/s10072-022-06169-7. PMID: 35672479Free PMC Article
Margoni M, Pagani E, Meani A, Storelli L, Mesaros S, Drulovic J, Barkhof F, Vrenken H, Strijbis E, Gallo A, Bisecco A, Pareto D, Sastre-Garriga J, Ciccarelli O, Yiannakas M, Palace J, Preziosa P, Rocca MA, Filippi M; MAGNIMS Study Group.
J Neurol Neurosurg Psychiatry 2022 Jul;93(7):741-752. Epub 2022 May 17 doi: 10.1136/jnnp-2022-328908. PMID: 35580993
Bossart J, Kamm CP, Kaufmann M, Stanikić M, Puhan MA, Kesselring J, Zecca C, Gobbi C, Rapold I, Kurmann R, Ammann S, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).
Mult Scler Relat Disord 2022 Apr;60:103706. Epub 2022 Feb 21 doi: 10.1016/j.msard.2022.103706. PMID: 35228114
Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive PH, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg H, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle J; NfL Reference Database in the Swiss Multiple Sclerosis Cohort Study Group.
Lancet Neurol 2022 Mar;21(3):246-257. doi: 10.1016/S1474-4422(22)00009-6. PMID: 35182510
Wattjes MP, Ciccarelli O, Reich DS, Banwell B, de Stefano N, Enzinger C, Fazekas F, Filippi M, Frederiksen J, Gasperini C, Hacohen Y, Kappos L, Li DKB, Mankad K, Montalban X, Newsome SD, Oh J, Palace J, Rocca MA, Sastre-Garriga J, Tintoré M, Traboulsee A, Vrenken H, Yousry T, Barkhof F, Rovira À; Magnetic Resonance Imaging in Multiple Sclerosis study group.; Consortium of Multiple Sclerosis Centres.; North American Imaging in Multiple Sclerosis Cooperative MRI guidelines working group.
Lancet Neurol 2021 Aug;20(8):653-670. Epub 2021 Jun 14 doi: 10.1016/S1474-4422(21)00095-8. PMID: 34139157

Therapy

Goris A, Vandebergh M, McCauley JL, Saarela J, Cotsapas C
Lancet Neurol 2022 Sep;21(9):830-842. doi: 10.1016/S1474-4422(22)00255-1. PMID: 35963264
Leguy S, Lefort M, Lescot L, Michaud A, Vukusic S, Le Page E, Edan G, Kerbrat A, Lebrun-Frenay C, De Sèze J, Laplaud DA, Wiertlewski S, Leray E, Michel L
J Neurol 2022 Oct;269(10):5571-5581. Epub 2022 Jun 23 doi: 10.1007/s00415-022-11215-7. PMID: 35737108
Bossart J, Kamm CP, Kaufmann M, Stanikić M, Puhan MA, Kesselring J, Zecca C, Gobbi C, Rapold I, Kurmann R, Ammann S, von Wyl V; Swiss Multiple Sclerosis Registry (SMSR).
Mult Scler Relat Disord 2022 Apr;60:103706. Epub 2022 Feb 21 doi: 10.1016/j.msard.2022.103706. PMID: 35228114
Lublin FD, Häring DA, Ganjgahi H, Ocampo A, Hatami F, Čuklina J, Aarden P, Dahlke F, Arnold DL, Wiendl H, Chitnis T, Nichols TE, Kieseier BC, Bermel RA
Brain 2022 Sep 14;145(9):3147-3161. doi: 10.1093/brain/awac016. PMID: 35104840
Ontaneda D, Raza PC, Mahajan KR, Arnold DL, Dwyer MG, Gauthier SA, Greve DN, Harrison DM, Henry RG, Li DKB, Mainero C, Moore W, Narayanan S, Oh J, Patel R, Pelletier D, Rauscher A, Rooney WD, Sicotte NL, Tam R, Reich DS, Azevedo CJ; North American Imaging in Multiple Sclerosis Cooperative (NAIMS).
Brain 2021 Aug 17;144(7):1974-1984. doi: 10.1093/brain/awab132. PMID: 33757115Free PMC Article

Prognosis

Knowles LM, Tingey JL, Newman AK, von Geldern G, Alschuler KN
Mult Scler Relat Disord 2022 Jul;63:103918. Epub 2022 May 28 doi: 10.1016/j.msard.2022.103918. PMID: 35700673
Portaccio E, Bellinvia A, Fonderico M, Pastò L, Razzolini L, Totaro R, Spitaleri D, Lugaresi A, Cocco E, Onofrj M, Di Palma F, Patti F, Maimone D, Valentino P, Confalonieri P, Protti A, Sola P, Lus G, Maniscalco GT, Brescia Morra V, Salemi G, Granella F, Pesci I, Bergamaschi R, Aguglia U, Vianello M, Simone M, Lepore V, Iaffaldano P, Filippi M, Trojano M, Amato MP
Brain 2022 Aug 27;145(8):2796-2805. doi: 10.1093/brain/awac111. PMID: 35325059
Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive PH, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg H, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle J; NfL Reference Database in the Swiss Multiple Sclerosis Cohort Study Group.
Lancet Neurol 2022 Mar;21(3):246-257. doi: 10.1016/S1474-4422(22)00009-6. PMID: 35182510
Lublin FD, Häring DA, Ganjgahi H, Ocampo A, Hatami F, Čuklina J, Aarden P, Dahlke F, Arnold DL, Wiendl H, Chitnis T, Nichols TE, Kieseier BC, Bermel RA
Brain 2022 Sep 14;145(9):3147-3161. doi: 10.1093/brain/awac016. PMID: 35104840
Wattjes MP, Ciccarelli O, Reich DS, Banwell B, de Stefano N, Enzinger C, Fazekas F, Filippi M, Frederiksen J, Gasperini C, Hacohen Y, Kappos L, Li DKB, Mankad K, Montalban X, Newsome SD, Oh J, Palace J, Rocca MA, Sastre-Garriga J, Tintoré M, Traboulsee A, Vrenken H, Yousry T, Barkhof F, Rovira À; Magnetic Resonance Imaging in Multiple Sclerosis study group.; Consortium of Multiple Sclerosis Centres.; North American Imaging in Multiple Sclerosis Cooperative MRI guidelines working group.
Lancet Neurol 2021 Aug;20(8):653-670. Epub 2021 Jun 14 doi: 10.1016/S1474-4422(21)00095-8. PMID: 34139157

Clinical prediction guides

Leguy S, Lefort M, Lescot L, Michaud A, Vukusic S, Le Page E, Edan G, Kerbrat A, Lebrun-Frenay C, De Sèze J, Laplaud DA, Wiertlewski S, Leray E, Michel L
J Neurol 2022 Oct;269(10):5571-5581. Epub 2022 Jun 23 doi: 10.1007/s00415-022-11215-7. PMID: 35737108
Knowles LM, Tingey JL, Newman AK, von Geldern G, Alschuler KN
Mult Scler Relat Disord 2022 Jul;63:103918. Epub 2022 May 28 doi: 10.1016/j.msard.2022.103918. PMID: 35700673
Portaccio E, Bellinvia A, Fonderico M, Pastò L, Razzolini L, Totaro R, Spitaleri D, Lugaresi A, Cocco E, Onofrj M, Di Palma F, Patti F, Maimone D, Valentino P, Confalonieri P, Protti A, Sola P, Lus G, Maniscalco GT, Brescia Morra V, Salemi G, Granella F, Pesci I, Bergamaschi R, Aguglia U, Vianello M, Simone M, Lepore V, Iaffaldano P, Filippi M, Trojano M, Amato MP
Brain 2022 Aug 27;145(8):2796-2805. doi: 10.1093/brain/awac111. PMID: 35325059
Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive PH, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg H, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle J; NfL Reference Database in the Swiss Multiple Sclerosis Cohort Study Group.
Lancet Neurol 2022 Mar;21(3):246-257. doi: 10.1016/S1474-4422(22)00009-6. PMID: 35182510
Lublin FD, Häring DA, Ganjgahi H, Ocampo A, Hatami F, Čuklina J, Aarden P, Dahlke F, Arnold DL, Wiendl H, Chitnis T, Nichols TE, Kieseier BC, Bermel RA
Brain 2022 Sep 14;145(9):3147-3161. doi: 10.1093/brain/awac016. PMID: 35104840

Recent systematic reviews

Carod-Artal FJ, Adjamian P, Vila Silván C, Bagul M, Gasperini C
Expert Rev Neurother 2022 Jun;22(6):499-511. Epub 2022 Jun 1 doi: 10.1080/14737175.2022.2075263. PMID: 35582858
Stefanou MI, Palaiodimou L, Katsanos AH, Milionis H, Kosmidou M, Lambadiari V, Halvatsiotis P, Ferentinos P, Andreadou E, Marinos G, Theodorou A, Tzartos JS, Voumvourakis K, Tsivgoulis G, Giannopoulos S
Mult Scler Relat Disord 2022 Feb;58:103395. Epub 2021 Nov 10 doi: 10.1016/j.msard.2021.103395. PMID: 35216778
Guitynavard F, Mirmosayyeb O, Razavi ERV, Hosseini M, Hosseinabadi AM, Ghajarzadeh M, Azadvari M
Mult Scler Relat Disord 2022 Feb;58:103392. Epub 2021 Nov 10 doi: 10.1016/j.msard.2021.103392. PMID: 35216773
Zailaie SA, Siddiqui JJ, Al Saadi RM, Anbari DM, S Alomari A, Cupler EJ
Immunol Invest 2022 May;51(4):947-962. Epub 2021 Mar 4 doi: 10.1080/08820139.2021.1887888. PMID: 33660581
Williams T, Zetterberg H, Chataway J
J Neurol 2021 Sep;268(9):3212-3222. Epub 2020 May 23 doi: 10.1007/s00415-020-09917-x. PMID: 32447549Free PMC Article

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