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Multiple sclerosis

MedGen UID:
10123
Concept ID:
C0026769
Disease or Syndrome
Synonyms: Disseminated Sclerosis; MS (Multiple Sclerosis); Multiple Sclerosis; Sclerosis, Disseminated; Sclerosis, Multiple
SNOMED CT: Disseminated sclerosis (24700007); MS - Multiple sclerosis (24700007); DS - Disseminated sclerosis (24700007); Multiple sclerosis (24700007)
 
Monarch Initiative: MONDO:0005301
Orphanet: ORPHA802

Definition

A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers. [from NCI]

Professional guidelines

PubMed

Jarius S, Aktas O, Ayzenberg I, Bellmann-Strobl J, Berthele A, Giglhuber K, Häußler V, Havla J, Hellwig K, Hümmert MW, Kleiter I, Klotz L, Krumbholz M, Kümpfel T, Paul F, Ringelstein M, Ruprecht K, Senel M, Stellmann JP, Bergh FT, Tumani H, Wildemann B, Trebst C; Neuromyelitis Optica Study Group (NEMOS)
J Neurol 2023 Jul;270(7):3341-3368. Epub 2023 Apr 6 doi: 10.1007/s00415-023-11634-0. PMID: 37022481Free PMC Article
Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977

Curated

UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Dobson R, Giovannoni G
Eur J Neurol 2019 Jan;26(1):27-40. Epub 2018 Nov 18 doi: 10.1111/ene.13819. PMID: 30300457
Cotsapas C, Mitrovic M, Hafler D
Handb Clin Neurol 2018;148:723-730. doi: 10.1016/B978-0-444-64076-5.00046-6. PMID: 29478610
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774
Compston A, Coles A
Lancet 2008 Oct 25;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7. PMID: 18970977

Diagnosis

Marcus R
JAMA 2022 Nov 22;328(20):2078. doi: 10.1001/jama.2022.14236. PMID: 36413229
Oh J, Vidal-Jordana A, Montalban X
Curr Opin Neurol 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622. PMID: 30300239
Doshi A, Chataway J
Clin Med (Lond) 2016 Dec;16(Suppl 6):s53-s59. doi: 10.7861/clinmedicine.16-6-s53. PMID: 27956442Free PMC Article
Howard J, Trevick S, Younger DS
Neurol Clin 2016 Nov;34(4):919-939. Epub 2016 Aug 18 doi: 10.1016/j.ncl.2016.06.016. PMID: 27720001
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Therapy

Alessandrini M, Preynat-Seauve O, De Bruin K, Pepper MS
S Afr Med J 2019 Sep 10;109(8b):70-77. doi: 10.7196/SAMJ.2019.v109i8b.14009. PMID: 31662153
Amatya B, Khan F, Galea M
Cochrane Database Syst Rev 2019 Jan 14;1(1):CD012732. doi: 10.1002/14651858.CD012732.pub2. PMID: 30637728Free PMC Article
Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sørensen PS, Thompson AJ, Wolinsky JS, Balcer LJ, Banwell B, Barkhof F, Bebo B Jr, Calabresi PA, Clanet M, Comi G, Fox RJ, Freedman MS, Goodman AD, Inglese M, Kappos L, Kieseier BC, Lincoln JA, Lubetzki C, Miller AE, Montalban X, O'Connor PW, Petkau J, Pozzilli C, Rudick RA, Sormani MP, Stüve O, Waubant E, Polman CH
Neurology 2014 Jul 15;83(3):278-86. Epub 2014 May 28 doi: 10.1212/WNL.0000000000000560. PMID: 24871874Free PMC Article
Meyer-Moock S, Feng YS, Maeurer M, Dippel FW, Kohlmann T
BMC Neurol 2014 Mar 25;14:58. doi: 10.1186/1471-2377-14-58. PMID: 24666846Free PMC Article
Lasky J
IDrugs 2004 Feb;7(2):166-72. PMID: 15057662

Prognosis

Cao F, Liu YC, Ni QY, Chen Y, Wan CH, Liu SY, Tao LM, Jiang ZX, Ni J, Pan HF
Autoimmun Rev 2023 Aug;22(8):103359. Epub 2023 May 16 doi: 10.1016/j.autrev.2023.103359. PMID: 37201621
Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P
Mult Scler 2020 Dec;26(14):1816-1821. Epub 2020 Nov 11 doi: 10.1177/1352458520970841. PMID: 33174475Free PMC Article
GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article
Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS
Lancet Public Health 2018 Jul;3(7):e323-e332. Epub 2018 Jun 14 doi: 10.1016/S2468-2667(18)30091-4. PMID: 29908859Free PMC Article
Leray E, Moreau T, Fromont A, Edan G
Rev Neurol (Paris) 2016 Jan;172(1):3-13. Epub 2015 Dec 21 doi: 10.1016/j.neurol.2015.10.006. PMID: 26718593

Clinical prediction guides

Louapre C, Bodini B, Lubetzki C, Freeman L, Stankoff B
Curr Opin Neurol 2017 Jun;30(3):231-236. doi: 10.1097/WCO.0000000000000456. PMID: 28362719
Bhargava P, Calabresi PA
Mult Scler 2016 Apr;22(4):451-60. Epub 2016 Jan 11 doi: 10.1177/1352458515622827. PMID: 26754801
Lee JY, Taghian K, Petratos S
Acta Neuropathol Commun 2014 Aug 27;2:97. doi: 10.1186/s40478-014-0097-7. PMID: 25159125Free PMC Article
Lamers I, Feys P
Mult Scler 2014 Jun;20(7):775-84. Epub 2014 Mar 24 doi: 10.1177/1352458514525677. PMID: 24664300
Traboulsee A, Li DK
Neuroimaging Clin N Am 2008 Nov;18(4):651-73, x. doi: 10.1016/j.nic.2008.07.001. PMID: 19068407

Recent systematic reviews

Ordoñez-Rodriguez A, Roman P, Rueda-Ruzafa L, Campos-Rios A, Cardona D
Int J Environ Res Public Health 2023 Mar 6;20(5) doi: 10.3390/ijerph20054624. PMID: 36901634Free PMC Article
Morales-Suarez-Varela M, Collado Sánchez E, Peraita-Costa I, Llopis-Morales A, Soriano JM
Nutrients 2021 Sep 13;13(9) doi: 10.3390/nu13093179. PMID: 34579056Free PMC Article
Naseri A, Nasiri E, Sahraian MA, Daneshvar S, Talebi M
Mult Scler Relat Disord 2021 May;50:102816. Epub 2021 Feb 4 doi: 10.1016/j.msard.2021.102816. PMID: 33571792
Corvillo I, Varela E, Armijo F, Alvarez-Badillo A, Armijo O, Maraver F
Eur J Phys Rehabil Med 2017 Dec;53(6):944-952. Epub 2017 Feb 17 doi: 10.23736/S1973-9087.17.04570-1. PMID: 28215060
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023
    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

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