HFD1 hexadecenal dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HFD1
Gene description: hexadecenal dehydrogenase
Primary source: SGD:S000004716
Locus tag: YMR110C
See related: AllianceGenome:SGD:S000004716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 4-hydroxybenzaldehyde dehydrogenase activity and carboxylate reductase activity. Involved in aldehyde catabolic process; sphingolipid metabolic process; and ubiquinone biosynthetic process from tyrosine. Located in lipid droplet. Is integral component of mitochondrial outer membrane. Used to study Sjogren-Larsson syndrome. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Orthologous to several human genes including ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (490394..491992, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-hydroxybenzaldehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 4-hydroxybenzaldehyde dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylate reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aldehyde catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular aldehyde metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular aldehyde metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular aldehyde metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process from tyrosine	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endosome	HDA more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	HDA more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hexadecenal dehydrogenase

NP_013828.1

EC 1.2.1.3

EC 1.2.1.64

Dehydrogenase involved in ubiquinone and sphingolipid metabolism; converts 4-hydroxybenzaldehyde into 4-hydroxybenzoate for ubiquinone anabolism, hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism; human homolog ALDH3A2, mutated in Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant; human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory growth phenotype of hfd1 null; data suggest that dual functions of Hfd1p have diverged in human ALDH3A1, ALDH3A2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

490394..491992 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182610.1 → NP_013828.1 TPA: hexadecenal dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013828.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZT3, Q04458

UniProtKB/TrEMBL

A0A6A5PPR4, A6ZMG7, B3LM01, B5VPN5, C7GW99, C8ZEW3, G2WKG0, N1NYS7

Conserved Domains (1) summary

cl11961
Location:11 → 466

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily