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    ETT1 Ett1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854216, updated on 13-Apr-2024

    Summary

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    Gene symbol
    ETT1
    Gene description
    Ett1p
    Primary source
    SGD:S000005577
    Locus tag
    YOR051C
    See related
    AllianceGenome:SGD:S000005577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NRO1; YOR29-02
    Summary
    Involved in translational termination. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (424846..426084, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ssRNA exonuclease RAT1 Neighboring gene phospholipid-translocating ATPase RSB1 Neighboring gene Tmc1p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit VHS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe. Rispal D, et al. RNA, 2011 Jul. PMID 21610214, Free PMC Article
    2. Structural and functional insights into Saccharomyces cerevisiae Tpa1, a putative prolylhydroxylase influencing translation termination and transcription. Henri J, et al. J Biol Chem, 2010 Oct 1. PMID 20630870, Free PMC Article
    3. Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress. Wallace EW, et al. Cell, 2015 Sep 10. PMID 26359986, Free PMC Article
    4. Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Kushner DB, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14671320, Free PMC Article
    5. Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. Van Dyke MW, et al. J Biol Chem, 2004 Jun 4. PMID 15044472

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nro1/Ett1 unexpectedly adopts a Tetratrico Peptide Repeat (TPR) fold, a motif often responsible for protein or peptide binding.
      Title: Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational termination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ett1p
    NP_014694.1
    • Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      424846..426084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183470.1 → NP_014694.1  TPA: Ett1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C7GLH8, D6W2B6, O00016, Q08421, Q6Q5I2
      UniProtKB/TrEMBL
      A0A8H4BV25, G2WMT1, N1P300
      Conserved Domains (1) summary
      pfam12753
      Location:1 → 410
      Nro1; Nuclear pore complex subunit Nro1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08421.1

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