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    ARR3 Arr3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856331, updated on 27-Jan-2024

    Summary

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    Gene symbol
    ARR3
    Gene description
    Arr3p
    Primary source
    SGD:S000006405
    Locus tag
    YPR201W
    See related
    AllianceGenome:SGD:S000006405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACR3
    Summary
    Enables antimonite transmembrane transporter activity; antiporter activity; and arsenite transmembrane transporter activity. Involved in antimonite transport and arsenite transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (939922..941136)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Arr1p Neighboring gene Arr2p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Y' element ATP-dependent helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane topology of the arsenite permease Acr3 from Saccharomyces cerevisiae. Wawrzycka D, et al. Biochim Biophys Acta Biomembr, 2017 Jan. PMID 27836640
    2. Identification of critical residues for transport activity of Acr3p, the Saccharomyces cerevisiae As(III)/H+ antiporter. Markowska K, et al. Mol Microbiol, 2015 Oct. PMID 26123064
    3. Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces cerevisiae. Maciaszczyk-Dziubinska E, et al. Biochim Biophys Acta, 2014 Mar. PMID 24291645
    4. Heterologous expression of the yeast arsenite efflux system ACR3 improves Arabidopsis thaliana tolerance to arsenic stress. Ali W, et al. New Phytol, 2012 May. PMID 22380876
    5. Microevolution of Cryptococcus neoformans driven by massive tandem gene amplification. Chow EW, et al. Mol Biol Evol, 2012 Aug. PMID 22334577

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.
      Title: Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors.
    2. Transmembrane topology of the arsenite permease Acr3 from Saccharomyces cerevisiae has been reported.
      Title: Transmembrane topology of the arsenite permease Acr3 from Saccharomyces cerevisiae.
    3. study identified several charged/polar and aromatic residues of Acr3p localized in the predicted transmembrane segments of the yeast arsenite transporter Acr3p that are important for As(III)/H+ antiport activity
      Title: Identification of critical residues for transport activity of Acr3p, the Saccharomyces cerevisiae As(III)/H+ antiporter.
    4. Heterologous expression of yeast ACR3 endows plants with greater arsenic resistance, but does not lower significantly arsenic tissue levels.
      Title: Heterologous expression of the yeast arsenite efflux system ACR3 improves Arabidopsis thaliana tolerance to arsenic stress.
    5. Data show that Fps1p in concert with the arsenite transporter Acr3p mediates arsenite efflux.
      Title: The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antimonite transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antimonite transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arsenite transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arsenite transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arsenite transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inorganic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimonite transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antimonite transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in arsenite transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arsenite transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arr3p
    NP_015527.1
    • Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; protein displays 10 transmembrane segments with cytoplasmically oriented N- and C-terminal domains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      939922..941136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184298.1 → NP_015527.1  TPA: Arr3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015527.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4J9, Q06598
      UniProtKB/TrEMBL
      A0A8H4F8H8, A6ZX73, B5VTX7, C7GP79, C8ZJN0, N1NWL6
      Conserved Domains (1) summary
      TIGR00832
      Location:30 → 391
      acr3; arsenical-resistance protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06598.1

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