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    SNU66 U4/U6-U5 snRNP complex subunit SNU66 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854485, updated on 13-Apr-2024

    Summary

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    Gene symbol
    SNU66
    Gene description
    U4/U6-U5 snRNP complex subunit SNU66
    Primary source
    SGD:S000005835
    Locus tag
    YOR308C
    See related
    AllianceGenome:SGD:S000005835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mRNA splicing, via spliceosome and maturation of 5S rRNA. Part of U4/U6 x U5 tri-snRNP complex. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (894624..896387, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene riboflavin transporter Neighboring gene Sly41p Neighboring gene RNA-processing protein NOP58 Neighboring gene diacylglycerol kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Broader roles of the ubiquitin-like protein Hub1 indicated by its yeast two-hybrid interactors. Varikkapulakkal A, et al. MicroPubl Biol, 2022. PMID 35098049, Free PMC Article
    2. Genome-wide identification of genes involved in growth and fermentation activity at low temperature in Saccharomyces cerevisiae. Salvadó Z, et al. Int J Food Microbiol, 2016 Nov 7. PMID 27442849
    3. LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels. Luhtala N, et al. Nucleic Acids Res, 2009 Sep. PMID 19596813, Free PMC Article
    4. A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. Kress TL, et al. Mol Cell, 2008 Dec 5. PMID 19061647, Free PMC Article
    5. Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Wilkinson CR, et al. Curr Biol, 2004 Dec 29. PMID 15620657

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of 5S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5S rRNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maturation of 5S rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit SNU66
    NP_014953.3
    • Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      894624..896387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183728.3 → NP_014953.3  TPA: U4/U6-U5 snRNP complex subunit SNU66 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014953.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W308, Q12420
      UniProtKB/TrEMBL
      A0A8H4F7F6, B3LJX3, N1P3S4
      Conserved Domains (1) summary
      pfam03343
      Location:7 → 571
      SART-1; SART-1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5ZWM_O.1
    5ZWO_O.1
    Q12420.1

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