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    SOL3 6-phosphogluconolactonase SOL3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856568, updated on 4-Feb-2024

    Summary

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    Gene symbol
    SOL3
    Gene description
    6-phosphogluconolactonase SOL3
    Primary source
    SGD:S000001206
    Locus tag
    YHR163W
    See related
    AllianceGenome:SGD:S000001206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in cytoplasm and nucleus. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (423724..424473)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Yap1801p Neighboring gene mitochondrial pyruvate carrier Neighboring gene bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 Neighboring gene U4/U6-U5 snRNP complex subunit PRP8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of a Saccharomyces cerevisiae mutant with improved ability to utilize xylose shows enhanced expression of proteins involved in transport, initial xylose metabolism, and the pentose phosphate pathway. Wahlbom CF, et al. Appl Environ Microbiol, 2003 Feb. PMID 12570990, Free PMC Article
    2. Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family. Shen WC, et al. Genetics, 1996 Jun. PMID 8725220, Free PMC Article
    3. Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Grüning NM, et al. Open Biol, 2014 Mar 5. PMID 24598263, Free PMC Article
    4. Engineering redox cofactor utilization for detoxification of glycolaldehyde, a key inhibitor of bioethanol production, in yeast Saccharomyces cerevisiae. Jayakody LN, et al. Appl Microbiol Biotechnol, 2013 Jul. PMID 23744286
    5. Identification of common traits in improved xylose-growing Saccharomyces cerevisiae for inverse metabolic engineering. Bengtsson O, et al. Yeast, 2008 Nov. PMID 19061191

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6-phosphogluconolactonase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphogluconolactonase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphogluconolactonase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphogluconolactonase SOL3
    NP_012033.2
    • 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      423724..424473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179294.1 → NP_012033.2  TPA: 6-phosphogluconolactonase SOL3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012033.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZT71, B3LSS7, B5VK90, D3DLB2, P38858
      UniProtKB/TrEMBL
      A0A8H4FB87, C8Z9W0, G2WFN7, N1P192
      Conserved Domains (1) summary
      TIGR01198
      Location:6 → 244
      pgl; 6-phosphogluconolactonase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38858.2

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