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    OLA1 Obg-like ATPase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852313, updated on 11-Apr-2024

    Summary

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    Gene symbol
    OLA1
    Gene description
    Obg-like ATPase
    Primary source
    SGD:S000000229
    Locus tag
    YBR025C
    See related
    AllianceGenome:SGD:S000000229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP hydrolysis activity. Located in cytoplasmic stress granule. Orthologous to human OLA1 (Obg like ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (290681..291865, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene chitin synthase CHS3 Neighboring gene putative thioredoxin peroxidase SCO2 Neighboring gene enoyl-[acyl-carrier-protein] reductase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The H2O2 stimulon in Saccharomyces cerevisiae. Godon C, et al. J Biol Chem, 1998 Aug 28. PMID 9712873
    2. Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae. Dannenmaier S, et al. J Biol Chem, 2021 Nov. PMID 34571008, Free PMC Article
    3. A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae. Samanfar B, et al. Mol Biosyst, 2014 Apr. PMID 24535059
    4. Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. Koller-Eichhorn R, et al. J Biol Chem, 2007 Jul 6. PMID 17430889
    5. Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae. Zhu M, et al. J Cell Sci, 2020 Jul 9. PMID 32503941

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress.
      Title: Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress.
    2. Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.
      Title: Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.
    3. deletion of OLA1 can increase premature stop codon bypass. It also increased the rate of protein biosynthesis measured by an inducible expression system.
      Title: A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Obg-like ATPase
    NP_009581.1
    • P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; positively regulates heat shock response; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      290681..291865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178373.1 → NP_009581.1  TPA: Obg-like ATPase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ27, P38219
      UniProtKB/TrEMBL
      A0A6A5Q4X6, A6ZKX1, B3LNB8, B5VDZ5, C7GM27, C8Z419, G2W932, N1P9C5
      Conserved Domains (1) summary
      PTZ00258
      Location:1 → 393
      PTZ00258; GTP-binding protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38219.1

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