Muc5ac mucin 5AC, oligomeric mucus/gel-forming [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Muc5acprovided by RGD
Full Name: mucin 5AC, oligomeric mucus/gel-formingprovided by RGD
Primary source: RGD:62001
See related: Ensembl:ENSRNOG00000055996 AllianceGenome:RGD:62001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07006032.1
Summary: Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to lipid; and response to vitamin A. Located in extracellular space. Used to study chronic obstructive pulmonary disease; dry eye syndrome; gastric ulcer; and stomach disease. Biomarker of asthma; gastric ulcer; otitis media; pulmonary fibrosis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (206293717..206326006)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196864336..196896475)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214725482..214756653)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats.
Title: Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats.
Molecular mechanism underlying miR130bSp1 transcriptional regulation in LPSinduced upregulation of MUC5AC in the bile duct epithelium.
Title: Molecular mechanism underlying miR‑130b‑Sp1 transcriptional regulation in LPS‑induced upregulation of MUC5AC in the bile duct epithelium.
Frequency of distal airways Clara cells was maintained while mRNA levels for the mucin-encoding genes Muc5B and Muc5ac in lung homogenates increased 1.9 and 3.9 times at 60 days of Pneumocystis infection.
Title: Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways.
Rat Muc2 was expressed in fetal intestinal goblet cells of surface epithelium of villi and developing Lieberkuhn crypts. In neonates and adults, Muc2 was expressed at luminal goblet cells of small and large intestine and at gastric mucous and glandular cells. Muc5ac protein was observed in embryonic gastric and lung samples; expression increased during development and postnatal and adult life.
Title: Temporal and spatial expression of Muc2 and Muc5ac mucins during rat respiratory and digestive tracts development.
concluded that subchronic inhalation of coal dust particulate matter 10 induces a decrease in expression of MUC5AC in male rats.
Title: Subchronic inhalation of coal dust particulate matter 10 induces bronchoalveolar hyperplasia and decreases MUC5AC expression in male Wistar rats.
Chronic Aspergillus fumigatus exposure upregulated the expression of MUC5AC in the airway epithelial cells and induced goblet cell hyperplasia, resulting in increased airway hypersensitivity in rats with chronic asthma.
Title: [Effects of chronic Aspergillus fumigatus exposure on the expression of mucin 5AC in the airways of asthmatic rats].
Chronic exposure to A. fumigatus upregulates the expression of MUC5AC.
Title: Chronic Aspergillus fumigatus exposure upregulates the expression of mucin 5AC in the airways of asthmatic rats.
The pulmonary mucus hypersecretion is associated with the increase of intrinsic Muc5ac expression in the rat airway exposure to acrolein.
Title: [Effects of acrolein exposure on the expression of Muc5ac in the airway of rats].
Dexamethasone substantially downregulates the expression of CLCA3 mRNA and Muc5ac protein in nasal mucosa in allergic rhinitis.
Title: [Effects of glucocorticoid on calcium-activated chloride channel expression in nasal mucosa in allergic rhinitis rats].
The expression of ICAM-1 and MUC5AC in lung tissue were both significantly higher in allergic rhinitis than that in control group.
Title: [Alteration of cytokines and mucin in lower respiratory tract in allergic rhinitis model in rats].

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

RH141818 (e-PCR)
- UniSTS:223810

D1Bda42 (e-PCR)
- UniSTS:239789

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within maintenance of lens transparency	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sulfur dioxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mucus layer	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin-5AC

Names: mucin 5, subtypes A and C, tracheobronchial/gastric

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.