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    NAA11 N-alpha-acetyltransferase 11, NatA catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 84779, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NAA11provided by HGNC
    Official Full Name
    N-alpha-acetyltransferase 11, NatA catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:28125
    See related
    Ensembl:ENSG00000156269 MIM:619432; AllianceGenome:HGNC:28125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARD2; ARD1B; hARD2
    Summary
    Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Part of NatA complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 1.1) and placenta (RPKM 0.8) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q21.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (79155376..79326061, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (82491029..82661846, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (80237801..80247215, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BMP2 inducible kinase Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15515 Neighboring gene progestin and adipoQ receptor family member 3 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene uncharacterized LOC124900723 Neighboring gene MPRA-validated peak5059 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:80169419-80169920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:80218690-80219258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:80274106-80274606 Neighboring gene uncharacterized LOC105377300 Neighboring gene glycerol kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer. Wang ZH, et al. Asian Pac J Cancer Prev, 2011. PMID 22292636
    2. Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation. Pang AL, et al. Epigenetics, 2011 Nov. PMID 22048246, Free PMC Article
    3. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. Huang GL, et al. World J Gastroenterol, 2010 Apr 28. PMID 20419844, Free PMC Article
    4. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. Arnesen T, et al. BMC Biochem, 2006 Apr 25. PMID 16638120, Free PMC Article
    5. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). Arnesen T, et al. BMC Biochem, 2009 May 29. PMID 19480662, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAA11 expression is tissue-specific and is epigenetically regulated by DNA methylation.
      Title: Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation.
    2. ARD1 protein was observed at 61.0% (50/82), 54.7% (87/159), 37.9% (25/66), 36.8% (7/19) in IDC, fibroadenoma, hyperplasia, and inflammation, respectively.
      Title: Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer.
    3. LOH in genes around D4S2964, including ARD1B and SEPT11 may play an important role in hepatocellular carcinoma development and progression
      Title: LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.
    4. hARD2, an N-alpha-acetyltransferase has 81 % sequence identity to hARD1. Its gene may originate from a eutherian-mammal-specific retrotransposition event. hARD2-NATH complexes may be responsible for protein N-alpha-acetylation in human cells.
      Title: Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.
    5. hARD2 (MGC10646) is a novel human protein N-alpha acetyltransferase
      Title: Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC10646

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-serine-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 11
    Names
    =N-terminal acetyltransferase complex ARD1 subunit homolog B
    ARD1 homolog B
    N-terminal acetyltransferase complex ARD1 subunit homolog B
    human arrest defective 2
    natA catalytic subunit Naa11
    NP_116082.1
    XP_016864266.1
    XP_016864267.1
    XP_016864268.1
    XP_054207090.1
    XP_054207091.1
    XP_054207092.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032693.3 → NP_116082.1  N-alpha-acetyltransferase 11

      See identical proteins and their annotated locations for NP_116082.1

      Status: VALIDATED

      Source sequence(s)
      AC023277, BC004552
      Consensus CDS
      CCDS47084.1
      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Related
      ENSP00000286794.4, ENST00000286794.5
      Conserved Domains (2) summary
      COG0456
      Location:1 → 149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47 → 122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      79155376..79326061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008779.2 → XP_016864268.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Conserved Domains (2) summary
      COG0456
      Location:1 → 149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47 → 122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. XM_017008778.3 → XP_016864267.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Conserved Domains (2) summary
      COG0456
      Location:1 → 149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47 → 122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    3. XM_017008777.2 → XP_016864266.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3
      Conserved Domains (2) summary
      COG0456
      Location:1 → 149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47 → 122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RNA

    1. XR_007057978.1 RNA Sequence

    2. XR_001741340.2 RNA Sequence

    3. XR_001741339.2 RNA Sequence

    4. XR_007057977.1 RNA Sequence

    5. XR_007057979.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      82491029..82661846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351117.1 → XP_054207092.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3

    2. XM_054351116.1 → XP_054207091.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3

    3. XM_054351115.1 → XP_054207090.1  N-alpha-acetyltransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q66K19, Q6P479, Q9BSU3

    RNA

    1. XR_008487051.1 RNA Sequence

    2. XR_008487050.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BSU3.3 GenPept UniProtKB/Swiss-Prot:Q9BSU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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