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    dlb deltaB [ Danio rerio (zebrafish) ]

    Gene ID: 30141, updated on 27-Mar-2024

    Summary

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    Official Symbol
    dlbprovided by ZNC
    Official Full Name
    deltaBprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-114
    See related
    Ensembl:ENSDARG00000004232 AllianceGenome:ZFIN:ZDB-GENE-980526-114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sc:d0400; etID309872.5
    Summary
    Predicted to enable Notch binding activity. Acts upstream of or within diencephalon development and midbrain development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adenohypophyseal placode; digestive system; ectoderm; nervous system; and neural plate. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL1 (delta like canonical Notch ligand 1) and DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (36693889..36701760)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (36093736..36101607)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene calpain, small subunit 1 a Neighboring gene zgc:153990 Neighboring gene uncharacterized LOC103911090 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. EphrinB2a in the zebrafish retinotectal system. Wagle M, et al. J Neurobiol, 2004 Apr. PMID 15007827
    2. Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish. DeCarvalho AC, et al. Dev Dyn, 2004 Apr. PMID 15042710
    3. DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock. Wright GJ, et al. Development, 2011 Jul. PMID 21653612
    4. Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. Del Bene F, et al. Cell, 2008 Sep 19. PMID 18805097, Free PMC Article
    5. The vesicular integral protein-like gene is essential for development of a mechanosensory system in zebrafish. Chong M, et al. Dev Neurobiol, 2008 Oct. PMID 18712783

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within diencephalon development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within diencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    delta-like protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130958.1 → NP_571033.1  delta-like protein B precursor

      See identical proteins and their annotated locations for NP_571033.1

      Status: PROVISIONAL

      Source sequence(s)
      AF006488
      UniProtKB/Swiss-Prot
      O57409
      UniProtKB/TrEMBL
      Q1LYD2
      Related
      ENSDARP00000021660.7, ENSDART00000019259.9
      Conserved Domains (3) summary
      cd00054
      Location:311 → 346
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01414
      Location:141 → 203
      DSL; Delta serrate ligand
      pfam07657
      Location:21 → 75
      MNNL; N terminus of Notch ligand

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      36693889..36701760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O57409.1 GenPept UniProtKB/Swiss-Prot:O57409

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