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    TSPY2 testis specific protein Y-linked 2 [ Homo sapiens (human) ]

    Gene ID: 64591, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TSPY2provided by HGNC
    Official Full Name
    testis specific protein Y-linked 2provided by HGNC
    Primary source
    HGNC:HGNC:23924
    See related
    Ensembl:ENSG00000168757 AllianceGenome:HGNC:23924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSPYQ1
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in several processes, including gonadal mesoderm development; nucleosome assembly; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 29.2) See more
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    Genomic context

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    See TSPY2 in Genome Data Viewer
    Location:
    Yp11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (6246223..6249018)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (10224454..10227249, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (6114264..6117059)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene DLGAP5 pseudogene 1 Neighboring gene testis expressed transcript, Y-linked 23B Neighboring gene family with sequence similarity 197 Y-linked member 9 Neighboring gene testis specific protein Y-linked 11, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of a new TSPY gene family member in Yq (TSPYq1). Ratti A, et al. Cytogenet Cell Genet, 2000. PMID 10773691
    2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC103998

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific Y-encoded protein 2
    Names
    testis-specific Y-encoded protein Q1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022573.4 → NP_072095.2  testis-specific Y-encoded protein 2

      See identical proteins and their annotated locations for NP_072095.2

      Status: VALIDATED

      Source sequence(s)
      AC006335
      Consensus CDS
      CCDS35465.1
      UniProtKB/Swiss-Prot
      A6NKD2
      UniProtKB/TrEMBL
      Q540R4
      Related
      ENSP00000314077.4, ENST00000320701.9
      Conserved Domains (1) summary
      cl08298
      Location:126 → 288
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      6246223..6249018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262569.5 → XP_005262626.1  testis-specific Y-encoded protein 2 isoform X1

      UniProtKB/TrEMBL
      A6NGT6, Q540R4
      Related
      ENSP00000372512.1, ENST00000383042.1
      Conserved Domains (1) summary
      cl08298
      Location:103 → 273
      NAP; Nucleosome assembly protein (NAP)

    2. XM_017030062.2 → XP_016885551.1  testis-specific Y-encoded protein 2 isoform X2

    RNA

    1. XR_001756004.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791821.1 Reference GRCh38.p14 PATCHES

      Range
      306266..309067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333414.1 → XP_054189389.1  testis-specific Y-encoded protein 2 isoform X3

      UniProtKB/TrEMBL
      F2Z2I4

    2. XM_054333415.1 → XP_054189390.1  testis-specific Y-encoded protein 2 isoform X4

    RNA

    1. XR_008485838.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      10224454..10227249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328321.1 → XP_054184296.1  testis-specific Y-encoded protein 2 isoform X6

    2. XM_054328320.1 → XP_054184295.1  testis-specific Y-encoded protein 2 isoform X5

      UniProtKB/TrEMBL
      A6NGT6

    RNA

    1. XR_008485524.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NKD2.1 GenPept UniProtKB/Swiss-Prot:A6NKD2

    Gene LinkOut

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