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    Prdx6b peroxiredoxin 6B [ Mus musculus (house mouse) ]

    Gene ID: 320769, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Prdx6bprovided by MGI
    Official Full Name
    peroxiredoxin 6Bprovided by MGI
    Primary source
    MGI:MGI:1336888
    See related
    Ensembl:ENSMUSG00000050114 AllianceGenome:MGI:1336888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aop2-rs1; Prdx5-rs1; Prdx6-ps1; Prdx6-rs1; 1-cysPrx-P1; Prdx6-rs1-ps; 4930414C22Rik
    Summary
    This intronless gene is similar to the multi-exon peroxiredoxin 6 gene located on chromosome 1. It is transcribed and the ORF is intact compared to that of the peroxiredoxin 6 gene. This gene could be considered a transcribed pseudogene based on a failure to detect the protein in vivo in PMID:14644414. However, NCBI is representing the protein due to mass spectrometry data in PMID:18614015, which detected at least one peptide that is specific for this protein. [provided by RefSeq, Mar 2011]
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    Genomic context

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    See Prdx6b in Genome Data Viewer
    Location:
    2 C3; 2 48.03 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (80122814..80125702)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (80292470..80295358)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 1A, calmodulin-dependent Neighboring gene STARR-seq mESC enhancer starr_04943 Neighboring gene predicted gene 13674 Neighboring gene STARR-positive B cell enhancer ABC_E5939 Neighboring gene predicted gene, 36153 Neighboring gene baculoviral IAP repeat-containing 2 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. Mo Y, et al. FEBS Lett, 2003 Dec 4. PMID 14644414
    2. Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Phelan SA, et al. Genomics, 1998 Nov 15. PMID 9806838
    3. Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences. Lyu MS, et al. Mamm Genome, 1999 Oct. PMID 10501973
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107184

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerophospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxiredoxin 6, related sequence 1
    Names
    anti-oxidant protein 2 related sequence 1
    peroxiredoxin 5 related sequence 1
    peroxiredoxin 6, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177256.5 → NP_796230.1  peroxiredoxin 6, related sequence 1

      See identical proteins and their annotated locations for NP_796230.1

      Status: VALIDATED

      Source sequence(s)
      AK161395, AL928587
      Consensus CDS
      CCDS38158.1
      UniProtKB/TrEMBL
      Q8BG37
      Related
      ENSMUSP00000133276.3, ENSMUST00000057072.6
      Conserved Domains (2) summary
      COG0450
      Location:5 → 199
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03016
      Location:7 → 222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      80122814..80125702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033713.1: Suppressed sequence

      Description
      NR_033713.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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