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    CG7220 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36129, updated on 10-May-2024

    Summary

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    Official Symbol
    CG7220provided by FlyBase
    Primary source
    FLYBASE:FBgn0033544
    Locus tag
    Dmel_CG7220
    See related
    AllianceGenome:FB:FBgn0033544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH28095; BEST:GH28095; Dmel\CG7220; Ube2W
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein monoubiquitination; and protein polyubiquitination. Predicted to be active in nucleus. Is expressed in adult fat body and eye. Orthologous to human UBE2W (ubiquitin conjugating enzyme E2 W). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG7220 in Genome Data Viewer
    Location:
    47B7-47B9; 2-63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10731335..10738370)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6618840..6625875)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene starry night Neighboring gene Rab3 Neighboring gene Carbonic anhydrase 13 Neighboring gene D-amino acid oxidase 1 Neighboring gene uncharacterized protein Neighboring gene Menage a trois 1 Neighboring gene long non-coding RNA:CR43605

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect. Champer J, et al. Genetics, 2019 May. PMID 30918006, Free PMC Article
    2. The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs. Zhang Y, et al. Elife, 2016 Oct 3. PMID 27692068, Free PMC Article
    3. The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster. Tsou WL, et al. Neurobiol Dis, 2015 Oct. PMID 26007638, Free PMC Article
    4. Isolation of mRNA from specific tissues of Drosophila by mRNA tagging. Yang Z, et al. Nucleic Acids Res, 2005 Oct 4. PMID 16204451, Free PMC Article
    5. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7220-PA
    CG7220-PB
    CG7220-PC
    CG7220-PD
    CG7220-PE
    CG7220-PF
    NP_001097261.1
    NP_001286293.1
    NP_610604.3
    NP_724964.2
    NP_724965.2
    NP_995809.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10731335..10738370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136760.4 → NP_610604.3  uncharacterized protein Dmel_CG7220, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610604.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T972
      Related
      FBpp0087311
      Conserved Domains (1) summary
      pfam00179
      Location:10 → 151
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_206087.3 → NP_995809.1  uncharacterized protein Dmel_CG7220, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T972
      Conserved Domains (1) summary
      pfam00179
      Location:10 → 151
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_165796.3 → NP_724965.2  uncharacterized protein Dmel_CG7220, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724965.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T972
      Related
      FBpp0087312
      Conserved Domains (1) summary
      pfam00179
      Location:10 → 151
      UQ_con; Ubiquitin-conjugating enzyme

    4. NM_001103791.2 → NP_001097261.1  uncharacterized protein Dmel_CG7220, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8B5, A8DY96, D3DMQ0
      Conserved Domains (1) summary
      pfam00179
      Location:46 → 187
      UQ_con; Ubiquitin-conjugating enzyme

    5. NM_001299364.1 → NP_001286293.1  uncharacterized protein Dmel_CG7220, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8B5, A8DY96, D3DMQ0
      Conserved Domains (1) summary
      pfam00179
      Location:46 → 187
      UQ_con; Ubiquitin-conjugating enzyme

    6. NM_165795.4 → NP_724964.2  uncharacterized protein Dmel_CG7220, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724964.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8B5, A8DY96, D3DMQ0
      Conserved Domains (1) summary
      pfam00179
      Location:46 → 187
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8B5 A1Z8B5
    Q8T972 Q8T972
    Q95SG1 Q95SG1

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