dbx1a developing brain homeobox 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dbx1aprovided by ZNC
Official Full Name: developing brain homeobox 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000128-8
See related: Ensembl:ENSDARG00000086393 AllianceGenome:ZFIN:ZDB-GENE-000128-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hlx1; hlx-1; fc15c04; wu:fc15c04; zgc:109861
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within cell differentiation in spinal cord. Predicted to be located in nucleus. Is expressed in several structures, including axial hypoblast; brain; neural tube; posterior neural rod; and prechordal plate. Orthologous to human DBX1 (developing brain homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (17024602..17028008, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (16772629..16776035, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HLX has a role in coordinating metabolic interplay regulates myeloid differentiation both in zebrafish and human hematopoietic stem and progenitor cells and in acute myeloid leukemia through partly overlapping pathways
Title: A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways.
We identified three areas of sequence conservation upstream of the dbx1a coding sequence and generated fluorescent reporter constructs driven by these predicted enhancer elements and the endogenous dbx1a promoter
Title: Chromosomal position mediates spinal cord expression of a dbx1a enhancer.
Hlx1 plays a role in zebrafish brain development
Title: Role of hlx1 in zebrafish brain morphogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fc15c04.x1 (e-PCR)
- UniSTS:203820

hlx1 (e-PCR)
- UniSTS:205613

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation in spinal cord	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation in spinal cord	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein DBX1-A

Names: H2.0-like homeobox 1; developing brain homeobox protein 1-A; homeobox protein hlx1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.