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    Ube2g2 ubiquitin-conjugating enzyme E2G 2 [ Mus musculus (house mouse) ]

    Gene ID: 22213, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ube2g2provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2G 2provided by MGI
    Primary source
    MGI:MGI:1343188
    See related
    Ensembl:ENSMUSG00000009293 AllianceGenome:MGI:1343188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBC7; Ubc7p; D10Xrf369; 1110003O05Rik
    Summary
    Enables identical protein binding activity and ubiquitin conjugating enzyme activity. Acts upstream of or within ERAD pathway. Located in cytosol and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 26.6), subcutaneous fat pad adult (RPKM 21.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2g2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77458155..77481824)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77622321..77645990)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene pituitary tumor-transforming 1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_27206 Neighboring gene STARR-positive B cell enhancer ABC_E6875 Neighboring gene small ubiquitin-like modifier 3 Neighboring gene STARR-positive B cell enhancer ABC_E3893 Neighboring gene STARR-seq mESC enhancer starr_27207 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene microRNA 1930 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene predicted gene, 48160

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation. Xu T, et al. Cell Death Differ, 2022 Aug. PMID 35110683, Free PMC Article
    2. Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Lee S, et al. Nat Struct Mol Biol, 2006 Mar. PMID 16462746, Free PMC Article
    3. F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. Chen BB, et al. Oncogene, 2012 May 17. PMID 22020328, Free PMC Article
    4. The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Chen B, et al. Proc Natl Acad Sci U S A, 2006 Jan 10. PMID 16407162, Free PMC Article
    5. Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. Liu W, et al. EMBO J, 2014 Jan 7. PMID 24366945, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ube2g2/gp78-mediated polyubiquitination involves preassembly of Lys 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2
      Title: A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Sumo3

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ERAD pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 G2
    Names
    E2 ubiquitin-conjugating enzyme G2
    ubiquitin carrier protein G2
    ubiquitin-conjugating enzyme 7 homolog
    ubiquitin-protein ligase G2
    NP_062777.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019803.3 → NP_062777.2  ubiquitin-conjugating enzyme E2 G2

      See identical proteins and their annotated locations for NP_062777.2

      Status: PROVISIONAL

      Source sequence(s)
      AC153864
      Consensus CDS
      CCDS56722.1
      UniProtKB/Swiss-Prot
      P60605
      UniProtKB/TrEMBL
      Q3U431, Q9QX59
      Related
      ENSMUSP00000133515.2, ENSMUST00000174510.8
      Conserved Domains (1) summary
      COG5078
      Location:1 → 163
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77458155..77481824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60605.1 GenPept UniProtKB/Swiss-Prot:P60605

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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