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    ST7-AS1 ST7 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 93653, updated on 17-Jun-2024

    Summary

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    Official Symbol
    ST7-AS1provided by HGNC
    Official Full Name
    ST7 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:16000
    See related
    Ensembl:ENSG00000227199 AllianceGenome:HGNC:16000
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST7AS1; ST7OT1
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    Genomic context

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    See ST7-AS1 in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116952446..116954334, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (118267615..118269503, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116592500..116594388, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene uncharacterized LOC124901857 Neighboring gene greater CFTR locus negative regulatory element CR9 Neighboring gene Sharpr-MPRA regulatory region 2110 Neighboring gene uncharacterized LOC105375465 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18564 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116593626-116594549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18567 Neighboring gene RNA, 5S ribosomal pseudogene 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18568 Neighboring gene NANOG hESC enhancer GRCh37_chr7:116609424-116609981 Neighboring gene ST7 overlapping transcript 4 Neighboring gene suppression of tumorigenicity 7 Neighboring gene tropomyosin 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18569 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:116659304-116660503 Neighboring gene microRNA 6132

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CAF-derived midkine promotes EMT and cisplatin resistance by upregulating lncRNA ST7-AS1 in gastric cancer. Yang KD, et al. Mol Cell Biochem, 2022 Nov. PMID 35588343
    2. The long noncoding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by stabilizing CARM1. Qin H, et al. Biochem Biophys Res Commun, 2019 Apr 23. PMID 30853182
    3. p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma. Sheng J, et al. Cancer Lett, 2021 Apr 10. PMID 33476649
    4. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. Vincent JB, et al. Genomics, 2002 Sep. PMID 12213198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAF-derived midkine promotes EMT and cisplatin resistance by upregulating lncRNA ST7-AS1 in gastric cancer.
      Title: CAF-derived midkine promotes EMT and cisplatin resistance by upregulating lncRNA ST7-AS1 in gastric cancer.
    2. p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/beta-catenin signalling pathway in glioma.
      Title: p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma.
    3. ST7-AS1 might mediate its oncogenic effect by signaling through CARM1-Sox-2 axis to enhance Sox-2 self-association and transactivation activity. Collectively, we have unraveled a ST7-AS1/CARM1/Sox-2 signaling axis in laryngeal squamous cell carcinoma and may have created novel interconnections between noncoding RNAs and cancer development.
      Title: The long noncoding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by stabilizing CARM1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • ST7 antisense RNA 1 (non-protein coding)
    • ST7 overlapping transcript 1 (antisense non-coding RNA)
    • ST7 overlapping transcript 1 (non-protein coding)
    • ST7 overlapping transcript antisense 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002330.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF400039
      Related
      ENST00000456775.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      116952446..116954334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      118267615..118269503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials