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    C19orf48P chromosome 19 open reading frame 48, pseudogene [ Homo sapiens (human) ]

    Gene ID: 84798, updated on 17-Jun-2024

    Summary

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    Official Symbol
    C19orf48Pprovided by HGNC
    Official Full Name
    chromosome 19 open reading frame 48, pseudogeneprovided by HGNC
    Gene description
    multidrug resistance-related protein
    Primary source
    HGNC:HGNC:29667
    See related
    Ensembl:ENSG00000293495 MIM:618864; AllianceGenome:HGNC:29667
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C19orf48; CA916798
    Expression
    Ubiquitous expression in prostate (RPKM 26.8), bone marrow (RPKM 14.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See C19orf48P in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (50797704..50804594, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (53887193..53894085, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51300961..51307851, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372439 Neighboring gene small integral membrane protein 47 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14997 Neighboring gene acid phosphatase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14998 Neighboring gene small nucleolar RNA, C/D box 88B Neighboring gene small nucleolar RNA, C/D box 88A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51305278-51305778 Neighboring gene small nucleolar RNA, C/D box 88C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15001 Neighboring gene long intergenic non-protein coding RNA 1869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10980 Neighboring gene kallikrein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human lung cancer drug resistance-related gene BC006151 regulates chemosensitivity in H446/CDDP cells. Li S, et al. Biol Pharm Bull, 2010. PMID 20686220
    2. C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients. Tykodi SS, et al. Clin Cancer Res, 2008 Aug 15. PMID 18698046, Free PMC Article
    3. [Cloning and sequence analysis of a new, full-length cDNA fragment of drug resistance-related gene in human lung adenocarcinoma]. Zhou XD, et al. Ai Zheng, 2002 Apr. PMID 12452007
    4. CA916798 affects growth and metastasis of androgen-dependent prostate cancer cells. He J, et al. Eur Rev Med Pharmacol Sci, 2018 Jul. PMID 30058677
    5. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Andreev DE, et al. Elife, 2015 Jan 26. PMID 25621764, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study in prostate cancer (PCa) cell lines showed that AR could specifically bind to the promoter regions of the CA916798 (C19orf48). Results suggest that dihydrotestosterone could initiate the transcription of CA916798, which further mediates the androgen-AR signaling pathway-dependent cell growth and metastasis of the PCa, revealing CA916798 as a downstream target of AR in PCa.
      Title: CA916798 affects growth and metastasis of androgen-dependent prostate cancer cells.
    2. Donor T-cell responses against the HLA-A*0201-restricted minor H antigen encoded by C19orf48 may contribute to renal cell carcinoma regression after MHC-matched allogeneic hematopoietic cell transplantation
      Title: C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients.
    3. a new drug resistance-related gene closely related to MDR of lung adenocarcinama induced by CDDP.
      Title: [Cloning and sequence analysis of a new, full-length cDNA fragment of drug resistance-related gene in human lung adenocarcinoma].
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • multidrug resistance-related protein
    • uncharacterized protein C19orf48

    Clone Names

    • MGC13170

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_171554.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325
      Related
      ENST00000597493.7

    2. NR_171555.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325

    3. NR_171556.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325
      Related
      ENST00000598463.5

    4. NR_171557.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325
      Related
      ENST00000597705.7

    5. NR_171558.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325

    6. NR_171559.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325
      Related
      ENST00000692421.1

    7. NR_171560.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325
      Related
      ENST00000596287.6

    8. NR_171561.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325
      Related
      ENST00000693315.1

    9. NR_171562.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325

    10. NR_171563.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010325
      Related
      ENST00000702900.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      50797704..50804594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      53887193..53894085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001290149.2: Suppressed sequence

      Description
      NM_001290149.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    2. NM_001290150.2: Suppressed sequence

      Description
      NM_001290150.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    3. NM_001290151.2: Suppressed sequence

      Description
      NM_001290151.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    4. NM_001290152.2: Suppressed sequence

      Description
      NM_001290152.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    5. NM_001290153.2: Suppressed sequence

      Description
      NM_001290153.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    6. NM_001290154.2: Suppressed sequence

      Description
      NM_001290154.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    7. NM_001290155.2: Suppressed sequence

      Description
      NM_001290155.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    8. NM_032712.3: Suppressed sequence

      Description
      NM_032712.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    9. NM_199249.3: Suppressed sequence

      Description
      NM_199249.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    10. NM_199250.3: Suppressed sequence

      Description
      NM_199250.3: This RefSeq was removed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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