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Series GSE93947 Query DataSets for GSE93947
Status Public on Apr 12, 2017
Title Oncogenic PIK3CA(H1047R) and CTNNB1(stab) in intestinal organoids
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Goals of the study was to compare transcripional and phenotypic response of mouse intestinal organoid cultures to the PIK3CA(H1047R) and CTNNB1(stab) oncogenes.
Overall design Two biological replicates of organoids with transgenic tdTomato-Luciferase, tdTomato-PIK3CAH1047R, tdTomato-CTNNB1stab or td-Tomato-PIK3CAH1047R-CTNNB1stab were analysed by RNA-Seq
By comparing 7-10 x 10E7 50bp paired end reads per library we identify transcriptional alterations in the intestinal epithelium following expression of each or both oncogenes,
Contributor(s) Riemer P, Morkel M
Citation(s) 28442534
Submission date Jan 23, 2017
Last update date May 15, 2019
Contact name Markus Morkel
Organization name Charité - Universitätsmedizin Berlin
Department Dept. of Pathology
Lab Laboratory of Molecular Tumour Pathology
Street address Charitéplatz 1
City Berlin
ZIP/Postal code 10117
Country Germany
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (8)
GSM2465529 LUC_987
GSM2465530 LUC_989
GSM2465531 CTNNB1_2250
BioProject PRJNA363058
SRA SRP097691

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Supplementary file Size Download File type/resource
GSE93947_GEO_Matrix_Processed.txt.gz 929.1 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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