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| Status |
Public on Mar 26, 2018 |
| Title |
Cancer Associated Fibroblasts are defined by a core set of epigenome changes that contribute to the tumor phenotype [Illumina_Omini 2.5-8_SNP] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
|
| Summary |
Cancer Associated Fibroblasts (CAFs) play an active role in tumourigenesis. It is unknown how the permanent phenotypic changes in CAFs are encoded at the molecular level. Here we use whole genome sequencing and microarray analysis to interrogate the epigenome, transcriptome and genome of patient-matched CAF and non-malignant prostate fibroblast (NPF) cells.
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| Overall design |
WGBS, RNA-seq, and microarrays were used to study epigenetics, transcriptomics and genetics in human cancer associated fibroblasts (CAFs) and non-malignant prostate fibroblasts (NPFs)
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| Contributor(s) |
Pidsley R, Mitchell L |
| Citation(s) |
29650553, 32571390 |
| Submission date |
Aug 15, 2016 |
| Last update date |
Jun 29, 2020 |
| Contact name |
Ruth Pidsley |
| E-mail(s) |
r.pidsley@garvan.org.au
|
| Organization name |
Garvan Institute of Medical Research
|
| Street address |
384 Victoria Street
|
| City |
Darlinghurst |
| State/province |
NSW |
| ZIP/Postal code |
2010 |
| Country |
Australia |
| |
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| Platforms (1) |
| GPL16104 |
Illumina HumanOmni2.5-8 BeadChip |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE86260 |
Cancer Associated Fibroblasts are defined by a core set of epigenome changes that contribute to the tumor phenotype |
|
| Relations |
| BioProject |
PRJNA338940 |
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