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| Status |
Public on May 09, 2015 |
| Title |
Influence of Erythropoietin on Microvesicles Derived from Mesenchymal Ste cells(MSC) protecting renal function of Chronic Kidney Disease |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
miRNA profiles of the MSC-MVs and EPO-MVs were analyzed with a quantitative PCR (qPCR)-based array of the whole mice genome. Further analysis revealed differences in the miRNAs of 212 EPO-MVs (fold change ≥ 1.5 compared to the MSC-MVs), which constituted approximately 22.64% of all of the evaluated mouse miRNAs. Of all of the differences, 70.28% of the changes in the EPO-MV group involved upregulation
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| Overall design |
To study the differential miRNA expression in MV and EPO-MV which might contributed to the better treatment in chronic kidney disease, we performed miRNA expression profiling of the culture supernatant of MSC with or without EPO incubation using the miRCURY LNA Array (v.18.0) (Exiqon, Vedbaek, Denmark).
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| Contributor(s) |
Wang Y, Zhao W |
| Citation(s) |
25998259 |
| |
| Submission date |
May 07, 2015 |
| Last update date |
Aug 13, 2015 |
| Contact name |
Yan Wang |
| E-mail(s) |
wangwang_890125@sina.com
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| Phone |
18262636355
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| Organization name |
the First Affiliated Hospital of Nanjing Medical University
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| Street address |
300 Guangzhou Road
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| City |
Nanjing |
| ZIP/Postal code |
210029 |
| Country |
China |
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| Platforms (1) |
| GPL20167 |
Exiqon miRCURY LNA microRNA Array, 7th generation REV - hsa, mmu & rno (miRBase v18.0) |
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| Samples (2) |
| GSM1678732 |
Microvesicles derived from erythropoietin co-cultured MSC |
| GSM1678733 |
Microvesicles derived from normal cultured MSC |
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| Relations |
| BioProject |
PRJNA283410 |
