|
| Status |
Public on Feb 18, 2015 |
| Title |
Stretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib
|
| |
|
| Overall design |
Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
|
| |
|
| Contributor(s) |
Vahedi G, Furumoto Y, Jiang K, Kanno Y, Roychoudhuri R, Restifo NP, Collins F, Sartorelli V, O'Shea JJ |
| Citation(s) |
25686607 |
| |
| Submission date |
Aug 18, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Golnaz Vahedi |
| Organization name |
National Institutes of Health
|
| Department |
NIAMS
|
| Lab |
Lymphocyte Cell Biology Section
|
| Street address |
9000 Rockville Pike Bldg 10 Rm 13C101A
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (3) |
| GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (21)
|
|
| Relations |
| BioProject |
PRJNA258386 |
| SRA |
SRP045570 |
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