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Status |
Public on Feb 18, 2015 |
Title |
Stretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells |
Organisms |
Homo sapiens; Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing
|
Summary |
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib
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Overall design |
Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
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Contributor(s) |
Vahedi G, Furumoto Y, Jiang K, Kanno Y, Roychoudhuri R, Restifo NP, Collins F, Sartorelli V, O'Shea JJ |
Citation(s) |
25686607 |
Submission date |
Aug 18, 2014 |
Last update date |
May 15, 2019 |
Contact name |
Golnaz Vahedi |
Organization name |
National Institutes of Health
|
Department |
NIAMS
|
Lab |
Lymphocyte Cell Biology Section
|
Street address |
9000 Rockville Pike Bldg 10 Rm 13C101A
|
City |
Bethesda |
State/province |
MD |
ZIP/Postal code |
20892 |
Country |
USA |
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Platforms (3) |
GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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Samples (21)
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Relations |
BioProject |
PRJNA258386 |
SRA |
SRP045570 |