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| Status |
Public on Jun 30, 2014 |
| Title |
A pivotal role of SRC-2 in Metastatic and Castration Resistant Prostate Cancer |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
SRC-2 is frequently amplified or overexpressed in metastatic prostate cancer patients. In this study, we used genetically engineered mice, overexpressing SRC-2 specifically in the prostate epithelium as a mouse model to examine the role of SRC-2 in prostate tumorigenesis. Over-expression of SRC-2 in PTEN heterozygous mice accelerates PTEN mutation induced tumor progression and develops a metastasis-prone cancer.
We used microarrays to examine the molecular profile of prostate-specific SRC-2 overexpression adult dorsal-lateral prostate in comparison with that of control PTENF/+ heterozygous deletion mice.
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| Overall design |
total RNA was extracted from dorsal-lateral prostate of 7 months old-PTEN flox/+ control and PTEN flox/+; Rosa26-SRC-2 OE/+ adult mice, followed by gene expression profiling using Affymetrix microarrays. Each sample contains pooled prostate RNA from 3 mice.
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| |
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| Contributor(s) |
Tsai SY, Tsai M |
| Citation(s) |
25295534 |
| Submission date |
Feb 04, 2014 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Hui-Ju Lee |
| E-mail(s) |
huijul@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Molecular & Cellular Biology
|
| Lab |
M-J Tsai; Sophia Y Tsai
|
| Street address |
One Baylor Plaza
|
| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA237437 |
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