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Series GSE3166 Query DataSets for GSE3166
Status Public on Aug 21, 2005
Title Influence of cyclical mechanical strain on global gene expression in human lamina cribrosa cells in vitro
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. The authors examined global gene expression profiles in lamina cribrosa cells exposed to cyclical mechanical stretch, with an emphasis on ECM genes.
Keywords: microarray, ECM, glaucoma, mechanical stretch, lamina cribrosa
Overall design n=3 stretch and static control experiments.
RNA pooled from each experiment and hybridised to individual experiment and control arrays.
Contributor(s) Kirwan RP, Fenerty CH, Crean' J, Wordinger RJ, Clark AF, O'Brien CJ
Citation(s) 16205625
Submission date Aug 18, 2005
Last update date Aug 10, 2018
Contact name Ruaidhri Patrick Kirwan
Organization name University College Dublin
Department Conway Institute of Biomolecular and Biomedical Research & School of Medicine and Medical Science
Lab Dr. Martin Leonard
Street address Belfield
City Dublin
State/province Leinster
ZIP/Postal code D4
Country Ireland
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (2)
GSM70917 static (control) experiment array
GSM70918 cyclical mechanical strain experiment (24 hours, 1 Hz , 15%)
BioProject PRJNA93007

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