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| Status |
Public on Apr 18, 2024 |
| Title |
The expression profiles of human lymphoma H9 cells after exposure to doxorubicin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
doxorubicin is commonly used for hematological malignancies. Since some of PTCL patients resistance to dox and die due to refractory disease or relapse, enhanced knowledge about drug response mechanisms is required to improve treatment outcome. we found an increased expression of HDAC3 in T lymphoma H9 cells following dox exprosure, we compared the gene expression profiles of H9 cells pre/post treated with doxorubicin to explore the potential mechanism of the high expression of HDAC3
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| Overall design |
To analyze the differential genes and pathways in H9 cells exposed to doxorubicin, we treated cells with doxorubicin for 6 hour,we then performed gene expression profiling analysis use data obtained from RNA-seq of doxorubicin-treated H9 cells and untreated H9 cells
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| Contributor(s) |
Li K, Hu J, Zhu J, Wang F |
| Citation missing |
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| Submission date |
Mar 03, 2024 |
| Last update date |
Apr 18, 2024 |
| Contact name |
ZHU JIA YAN |
| E-mail(s) |
zhujiayan126@126.com
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| Phone |
17850393822
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| Organization name |
Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
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| Street address |
197 Ruijin Er Rd
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| City |
Shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1083247 |
