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| Status |
Public on Oct 05, 2023 |
| Title |
Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We measured genes expression differences in antibody secreting cells from LynKO mice in following treatment with a BMI-1 inhibitor (PTC-028) or a vehicle control. BMI-1 inhibition lead to a reduction in antibody secreting cells in LynKO mice and in humans donors. We performed RNA sequencing to understand the impact of BMI-1 inhibition on antibody secreting cells in LynKO mice.
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| Overall design |
Antibody secreting cells (B220loCD138hi) were sort purified from LynKO mice 4 days after 12 consecutive days of PTC-028 treatment or vehicle control. RNAseq was undertaken on these cells.
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| Contributor(s) |
Polmear J, Jacobson KL |
| Citation(s) |
37799772 |
| Submission date |
Jul 28, 2023 |
| Last update date |
Jan 16, 2024 |
| Contact name |
Kim Good-Jacobson |
| E-mail(s) |
kim.jacobson@monash.edu
|
| Organization name |
Monash University
|
| Street address |
Gr Fl Reception (Bldg 77) 23 Innovation Walk
|
| City |
Clayton |
| State/province |
Victoria |
| ZIP/Postal code |
3800 |
| Country |
Australia |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA999632 |
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