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| Status |
Public on Nov 15, 2023 |
| Title |
Ancestral gestational exposure to widely used neonicotinoid thiacloprid leads to global DNA methylation alterations in spermatozoa in three generations of male mice [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Background: Neonicotinoids, a widely used class of insecticide that used is agriculture to control insect’s population, are serious public concern. Objectives: In this study, we examined the capacity of a neonicotinoid, thiacloprid (thia) to induce transgenerational effects in the male mice.
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| Overall design |
Methods: The pregnant outbred Swiss female mice were exposed to thia at embryonic days E6.5 to E15.5 using “0”, and “6” mg/kg/day doses. We analyzed the gene expression in embryonic testis in first and third generation embryos.
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| Contributor(s) |
Smagulova F |
| Citation(s) |
37973188 |
| |
| Submission date |
Jun 20, 2023 |
| Last update date |
Dec 06, 2023 |
| Contact name |
Fatima SMAGULOVA |
| E-mail(s) |
fatima.smagulova@inserm.fr
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| Phone |
+3323233662
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| Organization name |
Irset - U1085
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| Lab |
Chromatin, Epigenetics, Environment
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| Street address |
9 av. Prof. Léon Bernard
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| City |
Rennes |
| ZIP/Postal code |
35000 |
| Country |
France |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE235215 |
Ancestral gestational exposure to widely used neonicotinoid thiacloprid leads to global DNA methylation alterations in spermatozoa in three generations of male mice |
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| Relations |
| BioProject |
PRJNA985566 |
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